676329-14-9 Usage
Chemical structure
A cyclopropane ring with two hydroxyl groups, a fluorine atom at carbon 1, and an acetate group at carbon 2.
Stereochemistry
(1R,2S)-rel, indicating a specific spatial arrangement of atoms that can impact reactivity and biological activity.
Potential applications
Organic synthesis, as a building block for the synthesis of more complex molecules.
Functional groups
Cyclopropane ring, hydroxyl groups, fluorine atom, and acetate group.
Reactivity
The presence of the fluorine atom and acetate group may influence the reactivity of the compound in various chemical reactions.
Biological activity
The specific stereochemistry and functional groups may contribute to potential biological activity, depending on the target molecule or system.
Molecular weight
Approximately 144.14 g/mol (calculated from the molecular formula)
Solubility
The solubility of 1,2-Cyclopropanedimethanol,1-fluoro-,alpha2-acetate,(1R,2S)-rel-(9CI) is not provided, but it may be influenced by the presence of hydroxyl and acetate groups, which can interact with polar solvents.
Stability
The stability of 1,2-Cyclopropanedimethanol,1-fluoro-,alpha2-acetate,(1R,2S)-rel-(9CI) is not provided, but the presence of a cyclopropane ring and a fluorine atom may affect its stability under various conditions.
Synthesis
The synthesis of 1,2-Cyclopropanedimethanol,1-fluoro-,alpha2-acetate,(1R,2S)-rel-(9CI) would involve the formation of the cyclopropane ring, introduction of hydroxyl groups, fluorination at carbon 1, and acetylation at carbon 2.
Purity
The purity of the compound is not provided, but it is an important factor to consider when evaluating its potential applications and reactivity.
Safety and handling
Information on safety and handling is not provided, but it is essential to consider when working with 1,2-Cyclopropanedimethanol,1-fluoro-,alpha2-acetate,(1R,2S)-rel-(9CI), especially due to the presence of a fluorine atom and acetate group.
Check Digit Verification of cas no
The CAS Registry Mumber 676329-14-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,7,6,3,2 and 9 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 676329-14:
(8*6)+(7*7)+(6*6)+(5*3)+(4*2)+(3*9)+(2*1)+(1*4)=189
189 % 10 = 9
So 676329-14-9 is a valid CAS Registry Number.
676329-14-9Relevant academic research and scientific papers
Rosen, Thomas C.,De Clercq, Erik,Baizarini, Jan,Haufe, Guenter
, p. 229 - 237 (2004)
Diastereopure monofluorinated cyclopropanoid nucleosides were synthesized for biological studies. As key intermediates cis- and Trans-(±)-[1-fluoro-2-(acetoxymethyl)cyclopropyl]methanol were prepared starting from diastereopure fluorinated cyclopropanecarboxylates. The latter were synthesized by copper(I)-catalyzed cyclopropanation of α-fluorostyrene with ethyl diazoacetate. After reduction and O-acetylation the diastereomeric (2-fluoro-2-phenylcyclopropyl)methyl acetates were obtained. Oxidative degradation using RuO4 and reduction of the formed carboxyl group with borane gave the fluorinated alcohols, which were coupled with different nucleobases. After deprotection, the corresponding cyclopropanoid nucleosides of adenine, cytosine, guanine, thymine and uracil were obtained. Antiviral tests revealed for the cis-configured guanosine a low, but specific activity against HSV-1 and HSV-2. In addition low affinities of the adenine derivatives to adenosine receptors were detected.
