67633-95-8Relevant academic research and scientific papers
Wacker-type oxidation of internal alkenes using Pd(Quinox) and TBHP
Deluca, Ryan J.,Edwards, Jennifer L.,Steffens, Laura D.,Michel, Brian W.,Qiao, Xiaoxiao,Zhu, Chunyin,Cook, Silas P.,Sigman, Matthew S.
, p. 1682 - 1686 (2013/04/10)
The Pd-catalyzed TBHP-mediated Wacker-type oxidation of internal alkenes is reported. The reaction uses 2-(4,5-dihydro-2-oxazolyl)quinoline (Quinox) as ligand and TBHP(aq) as oxidant to deliver single ketone constitutional isomer products in a predictable fashion from electronically biased olefins. This methodology is showcased through its application on an advanced intermediate in the total synthesis of the antimalarial drug artemisinin.
INTRAMOLECULAR HYDROSILATION OF ACETYLENES: REGIOSELECTIVE FUNCTIONALIZATION OF HOMOPROPARGYL ALCOHOLS
Tamao, Kohei,Maeda, Kimio,Tanaka, Tetsu,Ito, Yoshihiko
, p. 6955 - 6956 (2007/10/02)
Platinum-catalyzed intramolecular hydrosilation of hydrodimethylsilyl ethers of homopropargyl alcohols proceeds regioselectively in a 5-exo-dig mode.The resulting vinylsilanes can be transformed into 3-alkanon-1-ol and 3-bromo-3-alken-1-ol derivatives by H2O2 oxidation and bromine cleavage, respectively.
