676348-33-7

Basic information

• Product Name: 2'-FLUOROBIPHENYL-3-CARBALDEHYDE
• Synonyms: AKOS BAR-0175;2'-FLUOROBIPHENYL-3-CARBALDEHYDE;2'-FLUORO-[1,1'-BIPHENYL]-3-CARBALDEHYDE;3-(2-Fluorophenyl)benzaldehyde
• CAS NO: 676348-33-7
• Molecular Formula: C₁₃H₉FO
• Molecular Weight: 200.21
• Product Categories: Aromatic Aldehydes & Derivatives (substituted)
• Mol File: 676348-33-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 178-179°C
• Boiling Point: 323.5 °C at 760 mmHg
• Flash Point: 215.6 °C
• Appearance: /
• Density: 1.173 g/cm³
• CAS DataBase Reference: 2'-FLUOROBIPHENYL-3-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-FLUOROBIPHENYL-3-CARBALDEHYDE(676348-33-7)
• EPA Substance Registry System: 2'-FLUOROBIPHENYL-3-CARBALDEHYDE(676348-33-7)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 676348-33-7(Hazardous Substances Data)

Usage

General Description

2'-FLUOROBIPHENYL-3-CARBALDEHYDE is a chemical compound with the molecular formula C13H9FO. It is a highly reactive aromatic compound that is used as a building block in the synthesis of various organic compounds. It is commonly used in the manufacture of pharmaceuticals, agrochemicals, and advanced materials. Its distinctive properties make it a valuable tool in the field of organic synthesis, and it is often utilized as a key intermediate in the production of complex molecules. Its fluorine-substituted aromatic ring imparts specific electronic and steric effects, making it a valuable tool in the development of new chemical compounds with unique properties and potential applications.

Upstream product

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Relevant articles and documents

Microwave-assisted organic acid-base-co-catalyzed tandem Meinwald rearrangement and annulation of styrylepoxides

A novel organic acid-base-co-catalyzed conversion of styrylepoxides into [1,1′-biaryl]-3-carbaldehydes was realized under microwave irradiation. Styrylepoxides first underwent an acid-catalyzed Meinwald rearrangement followed by a tandem base-catalyzed Michael addition, aldol addition, and aromatization sequence to generate [1,1′-biaryl]-3-carbaldehydes.

Discovery of phenylsulfonyl acetic acid derivatives with improved efficacy and safety as potent free fatty acid receptor 1 agonists for the treatment of type 2 diabetes

The free fatty acid receptor 1 (FFA1) has emerged as an attractive anti-diabetic target that mediates glucose-stimulated insulin secretion. Several FFA1 agonists have been reported, but many of them possessed somewhat high lipophilicity and/or molecular weight. Herein, we describe the identification of sulfone-carboxylic acid moiety with the multiple advantages of reducing lipophilicity, cytotoxicity and β-oxidation associated with compound 2. Further structure-activity relationship study based on the previleged scaffolds led to the discovery of 2-{(4-[(2’-chloro-[1,1’-biphenyl]-3-yl)methoxy]phenyl)sulfonyl}acetic acid (compound 20), which showed a better balance than compound 2 in terms of physicochemical properties, cytotoxicity profiles and pharmacokinetic properties. Subsequent in vivo studies demonstrated that compound 20 robustly improves the glucose tolerance both in normal and type 2 diabetic models without the risk of hypoglycemia. Compared to the high risk of TAK-875 induced liver toxicity, there was no significant adverse effects such as hepatic and renal toxicity were observed in the chronic toxicity studies of compound 20 even at the higher dose.