676449-35-7

Usage

Physical form

White to off-white crystalline powder

Solubility

Insoluble in water

Uses

Building block in the synthesis of pharmaceuticals, agrochemicals, dyes, and pigments

Chemical properties

Strong electron-withdrawing properties due to the presence of trifluoromethyl groups

Ongoing research

Potential biological activity in medicinal chemistry and drug discovery.

Upstream product

• 593249-82-2 4,5-bis[m-(trifluoromethyl)phenyl]-o-xylene 
• 676449-34-6 4,5-bis[m-(trifluoromethyl)phenyl]phthalic acid 

Relevant academic research and scientific papers

Synthesis and Some Properties of Aryl- and Aryloxy-Substituted Phthalocyanines and Their Metal Complexes: A Comparison with Porphyrazine and Naphthalocyanine Analogues

The preparation of new octakis[m-(trifluoromethyl)phenyl]-and octakis[m-(trifluoromethyl)phenoxy]phthalocyanines (6a and 6b) and their complexes with magnesium (5a, 5b) and indium (7a, 7b) is described. Their spectroscopic properties and solubilities are discussed in relation to those of metal-free and metallated octakis[m-(trifluoromethyl)phenyl]porphyrazine, as well as those of metal m-(trifluoromethyl)-phenyl- and m-(trifluoromethyl)phenoxy-substituted 2,3-naphthalocyanines. A drastic decrease in the solubilities of the metal-free phthalocyanines in CH 2Cl2 was observed on comparing them with m-CF3-phenyl-substituted porphyrazine. However, their solubilities in THF were high enough for NMR spectra to be recorded. Insertion of (chloro)indium into the cavities of these phthalocyanines noticeably enhances the solubilization of the macrocycles, including in CH2Cl2. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.