676463-08-4Relevant academic research and scientific papers
Reductive alkylation of thioureas: A highly practical synthesis of unsymmetrical N,N′-disubstituted thioureas
Ciszewski, Lech,Xu, Daquiang,Repi?, Oljan,Blacklock, Thomas J.
, p. 8091 - 8093 (2007/10/03)
A highly practical synthesis of unsymmetrical N,N′-disubstituted thioureas by the reductive alkylation of N-monosubstituted thioureas with aldehydes is described. N-Monosubstituted thioureas can in turn be synthesized by the reductive amination of thiourea with an appropriate aldehyde. This reductive alkylation methodology was also extended to carbamates.
