676476-90-7

Basic information

• Product Name: 2,2,2-trifluoro-1-(6-nitro-1H-indol-3-yl)ethan-1-one
• CAS NO: 676476-90-7
• Molecular Weight: 258.157
• Mol File: 676476-90-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2,2,2-trifluoro-1-(6-nitro-1H-indol-3-yl)ethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-trifluoro-1-(6-nitro-1H-indol-3-yl)ethan-1-one(676476-90-7)
• EPA Substance Registry System: 2,2,2-trifluoro-1-(6-nitro-1H-indol-3-yl)ethan-1-one(676476-90-7)

Safety Data

• Hazardous Substances Data: 676476-90-7(Hazardous Substances Data)

Usage

General Description

2,2,2-trifluoro-1-(6-nitro-1H-indol-3-yl)ethan-1-one is a chemical compound with the molecular formula C10H6F3NO3. It is a fluoroalkylated indole derivative with a trifluoromethyl ketone functional group attached to an indole ring. 2,2,2-trifluoro-1-(6-nitro-1H-indol-3-yl)ethan-1-one is often used in organic synthesis and medicinal chemistry as a building block for the synthesis of various pharmaceuticals and biologically active compounds. The presence of the trifluoromethyl group makes it a valuable synthetic intermediate for the introduction of fluorine atoms into complex molecules, which can enhance their biological activity and metabolic stability. Additionally, the nitro group and the indole moiety of this compound can confer specific biological and pharmacological properties to the molecules it is used to synthesize.

Upstream product

• 4769-96-4 6-nitroindole 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 10242-03-2 6-nitro-1H-indole-3-carboxylic acid 
• 934231-65-9 1-(1-benzyl-6-nitro-1H-indole-3-yl)-2,2,2-trifluoroethanone 

Relevant articles and documents

Synthesis of a Series of Diaminoindoles

A selection of 3,4-diaminoindoles were required for a recent drug discovery project. To this end, a 10-step synthesis was developed from 4-nitroindole. This synthesis was subsequently adapted and used to synthesize 3,5-; 3,6-; and 3,7-diaminoindoles from

NOVEL FUSED PYRROLE DERIVATIVE

Disclosed is a compound represented by the formula (1) below which is useful as a glucocorticoid receptor function regulating agent, an anti-inflammatory drug or an antidiabetic drug, or a pharmaceutically acceptable salt thereof. (1) [In the formula, R1 represents an aralkyl group or the like; R2 represents a hydrogen atom or the like; -W4=W5-W6=W7- represents a group expressed as the following formula: -CR4=CR5-CR6=CR7- (wherein R4, R5, R6 and R7 independently represent a group expressed as the following formula: -E-A (wherein E represents a single bond and A represents a hydrogen atom, a nitro group or the like)) or the like; R8 represents a group expressed as the following formula: -OR11 (wherein R11 represents a hydrogen atom or the like) or the like; R9 represents a trifluoromethyl group or the like; and R10 represents a group expressed as the following formula: -[C(R13)R14]n-R15 (wherein R13 and R14 independently represent a hydrogen atom or the like, n represents an integer of 0-10, and R15 represents a group expressed as the following formula: -N(R18)R19 (wherein R18 and R19 represent a monocyclic nitrogen-containing heterocyclic ring or the like together with a nitrogen atom to which they are bonded) or the like).]