67648-16-2

Upstream product

• 89-74-7 2,4-dimethylacetophenone. 
• 110-05-4 di-tert-butyl peroxide 
• 5162-82-3 3-chloro-4-methylbenzoic acid 
• 90887-98-2 2.4-Dimethyl-5-<β.β.β-trichlor-ethyl>-chlorbenzol 
• 861777-07-3 1-(5-chloro-2,4-dimethyl-phenyl)-butan-1-one 

Downstream Products

• 90919-19-0 5-Chlor-2,4-dimethyl-benzoesaeure-methylester 
• 46725-45-5 dimethyl 4,6-dimethylbenzene-1,3-dicarboxylate 

Relevant academic research and scientific papers

Preparation method for o-tolylacetic acid aryl formic acid derivative

The invention discloses a preparation method for an o-tolylacetic acid aryl formic acid derivative. According to the method, new C-C bonds can be formed, the organic o-tolylacetic acid aryl formic acid derivative is obtained, the good functional group tolerance is achieved, and the o-tolylacetic acid aryl formic acid derivative which cannot be easily obtained by adopting other methods can be synthesized; according to the method, adopted raw materials are easy to obtain, the yield is high, the reaction conditions are mild, the substrate range is wide, and after-treatment is simple and green.

Palladium-Catalyzed ortho-C-H Methylation of Benzoic Acids

A palladium-catalyzed methylation of C-H bonds of benzoic acids with di-tert-butyl peroxide as the methylating reagent under an external oxidant and ligand-free conditions has been achieved. The reaction is found to be directed by a weakly coordinating carboxyl group, offering a facile route for the synthesis of highly functionalized ortho-methyl benzoic acids.