676481-40-6

Basic information

• Product Name: Propanedioic acid, [2-[2-chloro-4-[[3-(phenylmethoxy)phenyl]thio]phenyl]ethyl]methyl-, diethyl ester
• CAS NO: 676481-40-6
• Molecular Formula: C29H31ClO5S
• Molecular Weight: 527.081
• Mol File: 676481-40-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Propanedioic acid, [2-[2-chloro-4-[[3-(phenylmethoxy)phenyl]thio]phenyl]ethyl]methyl-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedioic acid, [2-[2-chloro-4-[[3-(phenylmethoxy)phenyl]thio]phenyl]ethyl]methyl-, diethyl ester(676481-40-6)
• EPA Substance Registry System: Propanedioic acid, [2-[2-chloro-4-[[3-(phenylmethoxy)phenyl]thio]phenyl]ethyl]methyl-, diethyl ester(676481-40-6)

Safety Data

• Hazardous Substances Data: 676481-40-6(Hazardous Substances Data)

Upstream product

• 1023648-20-5 3-[3-(benzyloxy)phenylthio]-6-vinyl-1-chlorobenzene 
• 609-08-5 Diethyl methylmalonate 

Relevant articles and documents

An efficient total synthesis of a sphingosine-1-phosphate receptor agonist KRP-203

An efficient total synthesis of the S1P1 agonist, KRP-203, is described. The key step involves the conjugate addition of diethyl acetamidomalonate to a styrene compound to give the core structure of KRP-203. Multigram quantities of the targeted KRP-203, sufficient for several biological studies, were obtained in six steps with an overall yield of 58%.