676493-85-9

Upstream product

• 788825-14-9 tert-butyl 2-(4-tert-butyldimethylsilyloxyphenyl)-2-methylpropylcarbamate 
• 5351-07-5 2-(4-methoxy-phenyl)-2-methyl-propionitrile 
• 55770-61-1 2-(4-Hydroxyphenyl)-2-methylpropionitrile 
• 24424-99-5 di-tert-butyl dicarbonate 
• 210551-85-2 4-(2-amino-1,1-dimethyl-ethyl)-phenol 
• 210551-84-1 [2-(4-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-2-methylpropyl]amine 
• 210551-82-9 2-(4-tert-butyldimethylsilyloxyphenyl)-2-methylpropanenitrile 

Downstream Products

• 788825-15-0 tert-butyl 2-methyl-2-(4-phenoxyphenyl)propylcarbamate 
• 1638114-25-6 C₃₀H₄₂N₂O₇ 

Relevant academic research and scientific papers

A biomimetic catalytic aerobic functionalization of phenols

The importance of aromatic C-O, C-N, and C-S bonds necessitates increasingly efficient strategies for their formation. Herein, we report a biomimetic approach that converts phenolic C-H bonds into C-O, C-N, and C-S bonds at the sole expense of reducing dioxygen (O2) to water (H 2O). Our method hinges on a regio- and chemoselective copper-catalyzed aerobic oxygenation to provide ortho-quinones. ortho-Quinones are versatile intermediates, whose direct catalytic aerobic synthesis from phenols enables a mild and efficient means of synthesizing polyfunctional aromatic rings. The direct approach: Polyfunctional aromatic rings have been generated by direct functionalization of C-H bonds to C-O, C-N, and C-S bonds at the sole expense of reducing O2 to H2O. The method hinges on a regio- and chemoselective, copper-catalyzed aerobic oxygenation of phenols to provide ortho-quinones (see scheme), thus mimicking the ubiquitous biosynthetic pathway of melanogenesis.

Exploring the structure-activity relationship of the ethylamine portion of 3-iodothyronamine for rat and mouse trace amine-associated receptor 1

3-Iodothyronamine (1, T1AM) is a naturally occurring derivative of thyroid hormone that can potently activate the orphan G protein-coupled receptor (GPCR) known as the trace amine-associated receptor 1 (TAAR 1). We have previously found that modifying the outer ring of the phenoxyphenethylamine core scaffold of 1 can improve potency and provide potent agonists. In this study, we explored the tolerance of rat and mouse TAAR 1 (rTAAR1 and mTAAR1) for structural modifications in the ethylamine portion of 1. We found that incorporating unsaturated hydrocarbon substituents and polar, hydrogen-bond-accepting groups were beneficial for rTAAR1 and mTAAR1, respectively, providing compounds that were equipotent or more potent than 1. Additionally, we have discovered that a naphthyl group is an excellent isosteric replacement for the iodophenyl ring of 1.

DIARYL ETHERS AS OPIOID RECEPTOR ANTAGONIST

A compound of the formula (I) wherein the variables X1 to X10, R1 to R7 including R3', E, v, y, z, A and B are as described, or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mixtures thereof, useful for the treatment, prevention or amelioration of obesity and Related Diseases is disclosed.