676516-99-7Relevant academic research and scientific papers
Heterocycle fused cyclohexylglycine derivatives as novel dipeptidyl peptidase-IV inhibitors
Mastracchio, Anthony,Parmee, Emma R.,Leiting, Barbara,Marsilio, Frank,Patel, Reshma,Thornberry, Nancy A.,Weber, Ann E.,Edmondson, Scott D.
, p. 203 - 206 (2007/10/03)
A new class of potent inhibitors of dipeptidyl peptidase IV (DP-IV) for the treatment of type II diabetes are described. Presented herein is the synthesis of indole-fused and thiazole-fused cyclohexylglycines. Pyrrolidine-derived amides of these novel heterocycles led to the discovery of thiazole derivatives (3f) and (11a), both low nanomolar inhibitors of DP-IV (IC50 = 6 nM).
FUSED INDOLES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES
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, (2008/06/13)
The present invention is directed to fused indole derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is in
