67654-72-2Relevant academic research and scientific papers
Cyclols Revisited: Facile Synthesis of Medium-Sized Cyclic Peptides
Mendoza-Sanchez, Rodrigo,Corless, Victoria B.,Nguyen, Q. Nhu N.,Bergeron-Brlek, Milan,Frost, John,Adachi, Shinya,Tantillo, Dean J.,Yudin, Andrei K.
supporting information, p. 13319 - 13322 (2017/10/05)
Medium-sized rings, particularly the corresponding cyclic peptides, are challenging synthetic targets. In the present study, we report an approach to medium-sized cyclic peptides through targeted formation and collapse of cyclol intermediates. This methodology operates on β-amino imides derived from 2,5-diketopiperazines and offers a straightforward transition from frequently examined scaffolds in drug discovery to a rarely visited class of medium-sized rings.
N4-methylation changes the conformation of (3S,6S)-3-alkyl-6-benzylpiperazine-2,5-diones from folded to extended
Nakao, Michiyasu,Hiroyama, Yuta,Fukayama, Shintaro,Sano, Shigeki
, p. 37 - 44 (2016/05/31)
N4-methylation of (3S,6S)-3-alkyl-6-benzylpiperazine-2,5-diones (S,S)-1a-c was found to change their folded conformation to an extended conformation. Conformational aspects of N1- and/or N4-methylated (S,S)-1a-c were revealed by single crystal X-ray crystallography and 1H NMR spectroscopy.
N,N'-Bis(2-oxo-3-oxazolidinyl)phosphorodiamidic Azide: A Useful Coupling Agent in Peptide Synthesis
Katti, S. B.,Misra, P. K.,Haq, W.,Mathur, K. B.
, p. 3 - 4 (2007/10/02)
N,N'-Bis(2-oxo-3-oxazolidinyl)phosphorodiamidic azide (BOPA), has been developed as an efficient coupling reagent in peptide synthesis.Coupling reaction proceeds smoothly with no detectable racemization.
