676548-73-5

Upstream product

• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 
• 149157-63-1 (2R,3S)-2,4-dimethyl-3-<(4-methoxybenzyloxy)oxy>pentanal 
• 292638-85-8 acrylic acid methyl ester 
• 676548-69-9 (3S,4S)-2,4-dimethyl-3-(p-methoxybenzyloxy)-5-hexene 

Downstream Products

• 676549-65-8 C₆₁H₉₀O₁₁Si₂ 
• 676549-19-2 (2S,6S,8S)-6-Hydroxy-2,8-bis-(4-methoxy-benzyloxy)-1-((4S,6S)-6-{(4R,6R)-6-[(E)-(3S,4S)-4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-2,2-dimethyl-[1,3]dioxan-4-ylmethyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-11-trimethylsilanyl-undec-10-yn-4-one 
• 676549-17-0 (4S,6R,10S)-4,10-Bis-(4-methoxy-benzyloxy)-11-((4R,6R)-6-{(4R,6R)-6-[(E)-(3S,4S)-4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-2,2-dimethyl-[1,3]dioxan-4-ylmethyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-1-trimethylsilanyl-undeca-1,8-diyn-6-ol 
• 676549-23-8 C₅₉H₈₅IO₁₂ 
• 676549-21-6 C₅₉H₈₄O₁₂ 
• 676549-07-8 (4S,6R)-4-[(4R,6S)-4-Dimethylsilanyloxy-6-(4-methoxy-benzyloxy)-8-trimethylsilanyl-octa-1,7-diynyl]-6-[(E)-(3S,4S)-4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-2,2-dimethyl-[1,3]dioxane 
• 676549-09-0 (4R,6S)-4-[(E)-(3S,4S)-4-(4-Methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-6-[(S)-5-[(S)-2-(4-methoxy-benzyloxy)-4-trimethylsilanyl-but-3-ynyl]-2,2-dimethyl-[1,2]oxasilolan-(3E)-ylidenemethyl]-2,2-dimethyl-[1,3]dioxane 
• 676549-05-6 (4R,6S)-6-(4-Methoxy-benzyloxy)-1-{(4S,6R)-6-[(E)-(3S,4S)-4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-8-trimethylsilanyl-octa-1,7-diyn-4-ol 
• 676549-03-4 (4R,6S)-6-(tert-Butyl-dimethyl-silanyloxy)-1-{(4S,6R)-6-[(E)-(3S,4S)-4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-8-trimethylsilanyl-octa-1,7-diyn-4-ol 
• 676549-15-8 C₄₁H₅₈O₈ 
• 676548-82-6 (4S,6R)-4-Ethynyl-6-[(E)-(3S,4S)-4-(4-methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-2,2-dimethyl-[1,3]dioxane 
• 323192-62-7 (4S,5S)-4,6-dimethyl-5-(p-methoxybenzyloxy)-trans-hept-2-enal 
• 858676-66-1 (7S,9S,2'R,4'S,6'R)-1-(6'-(2-benzyldimethylsilylethenyl)-2'-phenyl-[1,3]dioxan-4'yl)-7,9-dimetheyl-6-hydroxy-8-(4-methoxyphenylmethoxy)-5-nonen-2-one 

Relevant academic research and scientific papers

Total synthesis of RK-397

An enantioselective synthesis of the polyene macrolide RK-397 is described. The use of the same eight-carbon building block twice for the construction of the polyol chain allowed for a highly convergent synthesis. The synthesis highlights stereoselective vinylogous aldol addition using a chiral bisphosphoramide as well as a sequential palladium-catalyzed cross-coupling reaction for the preparation of key fragments. Copyright

Total Synthesis of the Polyene-Polyol Macrolide RK-397, Featuring Cross-Couplings of Alkynylepoxide Modules

The total synthesis of the natural product RK-397 is based on a new synthetic strategy for assembling polyacetate structures, by efficient cross-coupling of nucleophilic terminal alkyne modules with electrophilic epoxides bearing another alkyne at the opp