676556-92-6

Basic information

• Product Name: 3-benzylamino-8-methyl-8H-quino[4,3,2-kl]acridine
• Synonyms: 3-benzylamino-8-methyl-8H-quino[4,3,2-kl]acridine
• CAS NO: 676556-92-6
• Molecular Weight: 387.484
• Mol File: 676556-92-6.mol

Chemical Properties

• CAS DataBase Reference: 3-benzylamino-8-methyl-8H-quino[4,3,2-kl]acridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-benzylamino-8-methyl-8H-quino[4,3,2-kl]acridine(676556-92-6)
• EPA Substance Registry System: 3-benzylamino-8-methyl-8H-quino[4,3,2-kl]acridine(676556-92-6)

Safety Data

• Hazardous Substances Data: 676556-92-6(Hazardous Substances Data)

Upstream product

• 100-46-9 benzylamine 
• 410533-61-8 3-chloro-8-methyl-8H-quino[4,3,2-kl]acridine 

Relevant articles and documents

Synthesis and properties of bioactive 2- and 3-amino-8-methyl-8H-quino[4,3,2-kl]acridine and 8,13-dimethyl-8H-quino[4,3,2-kl]acridinium salts.

Cyclisation of 9-(benzotriazol-1-yl)acridine to the pentacycle 8H-quino[4,3,2-kl]acridine in a range of low-boiling solvents is mechanistically distinct from previously published photochemical (carbene) and thermolytic (radical) cyclisations. Fragmentation of the triazole ring of to a diazonium intermediate, and its subsequent heterolysis (-N(2)) and cyclisation is facilitated by solvation of intermediate zwitterionic species. Derivatives of 2- and 3-aminoquinoacridines methylated in the 8-position can be converted to 8,13-dimethylquino[4,3,2-kl]acridinium iodide salts with methyl iodide and were required for biological examination as potential telomerase inhibitors. The chloro group in 3-chloro-8-methyl-8H-quino[4,3,2-kl]acridine can be replaced efficiently by benzylamino, 4-morpholinyl and cyano substituents in palladium(0) mediated reactions.