676558-77-3Relevant academic research and scientific papers
A new 'one-pot' synthesis of 2-substituted 3-nitro pyrrolidines through a multicomponent domino reaction
Baricordi, Nikla,Benetti, Simonetta,Biondini, Gisella,De Risi, Carmela,Pollini, Gian P.
, p. 1373 - 1375 (2004)
An efficient 'one-pot' synthesis of the title compounds based on a multicomponent domino reaction between imines and 3-nitro-1-propanol methanesulfonate has been developed.
Diastereoselective addition of higher order cuprates and zinc-copper reagents to imines derived from (S)-1-phenylethylamine
Bandini, Marco,Cozzi, Pier Giorgio,Umani-Ronchi, Achille,Villa, Marzia
, p. 8103 - 8110 (2007/10/03)
The diastereoselective addition of higher order (H.O.) cuprates and zinc-copper reagents to aliphatic and aromatic chiral imines derived from (S)-1-phenylethylamine was examined. Aliphatic chiral imines react with (Allyl)2CuCNLi2 and (n-Bu)2Cu(CN)Li2 in the presence of BF3-Et2O and Me3SiCl in high diastereoselection, while c-C6H11Cu(CN)ZnI and AllylCu(CN)ZnBr afford chiral amines in comparable yields without additives. Moreover the synthesis of a key intermediate towards a δ-amino-acid was reported.
