676570-37-9

Basic information

• Product Name: TETANUS TOXIN
• Synonyms: tetanus toxin from clostridium tetani
• CAS NO: 676570-37-9
• Molecular Weight: 0
• Product Categories: BacteriaNeurotransmission;Glycinergics;Cell Signaling and Neuroscience;Neurotransmitters;Toxins and Venoms
• Mol File: 676570-37-9.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• Solubility: H2O: soluble
• CAS DataBase Reference: TETANUS TOXIN(CAS DataBase Reference)
• NIST Chemistry Reference: TETANUS TOXIN(676570-37-9)
• EPA Substance Registry System: TETANUS TOXIN(676570-37-9)

Safety Data

• Hazard Codes: T+
• Statements: 26/27/28
• Safety Statements: 28-36/37/39-45-36/37
• RIDADR: UN 3462 6.1/PG 1
• WGK Germany: 3
• Hazardous Substances Data: 676570-37-9(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 676570-37-9 differently. You can refer to the following data:
1. Tetanus toxin is the tetanus toxin produced by the anaerobic bacillus?Clostridium tetani.
2. Tetanus toxin from Clostridium tetani has been used as the exocytosis inhibitor/Golgi-dependent secretion to examine whether secretory carrier membrane protein (SCAMP5) stimulated α-synuclein secretion via the conventional Golgi-dependent pathway. It has also been used in peripheral blood mononuclear cells (PBMCs) culture for?T?cell?proliferation screening.

General Description

Tetanus toxin is also known as tetanospasmin. It is a 150-kDa protein, produced by Clostridium tetani. This protein consists of a light and a heavy chain.

Biochem/physiol Actions

Binds to polysialogangliosides acceptors on surface of all peripheral presynaptic nerve terminals. Internalized by receptor-mediated endocytosis and carried to spinal cord and brain by transsynaptic retrograde transport. Blocks the release of glycine from inhibitory interneurons of the spinal cord. Cleaves synaptobrevin (VAMP-2), and blocks synaptic vesicle exocytosis in vivo.