676581-54-7Relevant articles and documents
Structural studies of 2-methyl-7-substituted pyrazolo[1,5-a]pyrimidines
Frizzo, Clarissa P.,Martins, Marcos A.P.,Marzari, Mara R. B.,Campos, Patrick T.,Claramunt, Rosa M.,Garcia, M. Angeles,Sanz, Dionisia,Alkorta, Ibon,Elguero, Jose
, p. 1259 - 1268 (2010)
Six pyrazolo[1,5-a]pyrimidines bearing a 7-trifluoromethyl (three compounds), a 7-trichloromethyl (two compounds), and a 7-ethoxycarbonyl (one compound) have been structurally characterized. The new X-ray structures of 2-methyl-5-(p-bromophenyl)-7-trifluoromethylpyrazolo[1,5-a]pyrimidine (3) and 2-methyl-7-trichloromethylpyrazolo[1,5-a]pyrimidine (4) are reported. The combined use of GIAO/B3LYP/6-311++G(d,p) calculations with NMR spectroscopy in solution and in the solid state allows to establish some general rules that can be useful for characterizing related compounds. Compounds 3 and 4 present in the solid-state interesting intra- and intermolecular halogen bonds.