67659-36-3

Usage

Uses

Used in Pharmaceutical Industry:
(R)-1,1-DIPHENYL-2-AMINOPROPANE is used as a precursor for the preparation of trisubstituted dihydroisoquinoline derivatives via the Bischler-Napieralski reaction. This reaction is a key synthetic method for the formation of various bioactive compounds, including those with potential therapeutic applications. The chiral nature of (R)-1,1-DIPHENYL-2-AMINOPROPANE allows for the selective synthesis of enantiomerically pure products, which is crucial for the development of drugs with improved efficacy and reduced side effects.
Additionally, due to its structural features, (R)-1,1-DIPHENYL-2-AMINOPROPANE may also find use in other industries such as materials science for the development of novel polymers or in the synthesis of chiral ligands for asymmetric catalysis. However, the specific applications in these fields would require further research and development to fully explore the compound's potential.

InChI:InChI=1/C15H17N/c1-12(16)15(13-8-4-2-5-9-13)14-10-6-3-7-11-14/h2-12,15H,16H2,1H3/t12-/m1/s1

Upstream product

• 37577-07-4 Norpseudoephedrine 
• 71-43-2 benzene 
• 3139-55-7 1,1-diphenylisopropylamine 

Downstream Products

• 1250258-74-2 N-((R)-1,1-diphenylpropan-2-yl)pivalamide 
• 1301743-00-9 C₅₄H₄₄N₂ 
• 1301743-20-3 C₇₈H₅₆N₂ 

Relevant academic research and scientific papers

COMPOSITIONS AND METHODS FOR CYCLOFRUCTANS AS SEPARATION AGENTS

The present invention relates to derivatized cyclofructan compounds, compositions comprising derivatized cyclofructan compounds, and methods of using compositions comprising derivatized cyclofructan compounds for chromatographic separations of chemical species, including enantiomers. Said compositions may comprise a solid support and/or polymers comprising derivatized cyclofructan compounds.

Development of new HPLC chiral stationary phases based on native and derivatized cyclofructans

An unusual class of chiral selectors, cyclofructans, is introduced for the first time as bonded chiral stationary phases. Compared to native cyclofructans (CFs), which have rather limited capabilities as chiral selectors, aliphatic-and aromatic-functionalized CF6s possess unique and very different enantiomeric selectivities. Indeed, they are shown to separate a very broad range of racemic compounds. In particular, aliphatic-derivatized CF6s with a low substitution degree baseline separate all tested chiral primary amines. It appears that partial derivatization on the CF6 molecule disrupts the molecular internal hydrogen bonding, thereby making the core of the molecule more accessible. In contrast, highly aromaticfunctionalized CF6 stationary phases lose most of the enantioselective capabilities toward primary amines, however they gain broad selectivity for most other types of analytes. This class of stationary phases also demonstrates high "loadability" and therefore has great potential for preparative separations. The variations in enantiomeric selectivity often can be correlated with distinct structural features of the selector. The separations occur predominantly in the presence of organic solvents.

Reactions of amino alcohols in superacid: the direct observation of dicationic intermediates and their application in synthesis.

[reaction: see text]. The chemistry of amino alcohols has been studied in superacidic media, and these compounds have been found to ionize cleanly to the dication intermediates. Several dicationic species have been directly observed by low-temperature 13C NMR, including those from epinephrine (adrenaline) and synephrine. Amino alcohols react (70-99% yields) with C6H6 in triflic acid (CF3SO3H) by electrophilic aromatic substitution.