676591-55-2

Upstream product

• 676591-54-1 (R)-1-phenyl-9-triisopropylsilanyloxynon-5-yn-4-ol 
• 1821-12-1 4-Phenylbutyric acid 
• 177756-65-9 N-methoxy-N-methyl-4-phenylbutyramide 
• 676591-53-0 1-phenyl-9-triisopropylsilanyloxynon-5-yn-4-one 

Downstream Products

• 676591-60-9 (R)-triisopropyl-(6-methoxy-9-phenylnon-4-enyloxy)-silane 
• 878168-57-1 (2R,4S,6R)-4-((E)-(R)-6-Methoxy-9-phenyl-non-4-enyl)-2-methyl-6-phenethyl-[1,3]dioxane-4-carbonitrile 
• 878168-56-0 (2S,4R,6S)-4-((E)-(R)-6-Methoxy-9-phenyl-non-4-enyl)-2-methyl-6-phenethyl-[1,3]dioxane-4-carbonitrile 
• 676591-61-0 (R)-6-methoxy-9-phenylnon-4-en-1-ol 
• 676591-62-1 (R)-(9-iodo-4-methoxynon-5-enyl)benzene 
• 676591-56-3 (E)-(R)-8-Methoxy-2,2-dimethyl-11-phenyl-undec-6-enenitrile 

Relevant academic research and scientific papers

Stereoselectivity of intramolecular SN′ cyclizations of alkyllithium reagents on methoxy alkenes

The cyclization of alkyllithium reagents onto methoxy alkenes has been investigated. The alkyllithium reagent was generated by reductive lithiation of an alkyl nitrile. In an unbiased substrate, a methoxy leaving group attached to a stereogenic secondary

Intramolecular S(N)2' cyclization of an alkyllithium species onto a methoxy allyl ether is syn selective.

The preference for syn- or anti-addition of an intramolecular S(N)2[prime or minute] cyclization of an alkyllithium species onto a methoxy allyl ether has been proven unequivocally to take place by a syn S(N)2[prime or minute] mechanism.