676596-81-9Relevant academic research and scientific papers
Three-component coupling approach toward the synthesis of a resorcylic acid lactone framework
Sugiyama, Sakae,Fuse, Shinichiro,Takahashi, Takashi
, p. 6654 - 6658 (2011)
A resorcylic acid lactone (RAL) framework was constructed based on a three-component coupling approach. The key step was the intermolecular alkylation of a protected cyanohydrin with an aromatic scaffold, and the subsequent carbonylative esterification of the aryl iodide with an alcohol. This sequence allowed the rapid assembly of three components without extra protection/deprotection steps. This synthetic strategy enables the ketone at the 2′ position to be masked as a protected cyanohydrin during the ester formation, thus avoiding an undesired isocoumarin formation. This method should be widely applicable to the synthesis of various types of RAL frameworks.
Enantioselective Palladium-Catalyzed Heck-Heck Cascade Reactions: Ready Access to the Tetracyclic Core of Lycorane Alkaloids
Coya, Estibaliz,Sotomayor, Nuria,Lete, Esther
supporting information, p. 3206 - 3214 (2015/11/03)
A rapid and efficient access to a wide variety of enantiomerically enriched C-11b substituted lycorane analogues can be achieved via a catalytic asymmetric Heck-Heck 6-exo/6-endo cascade reaction in the presence of (R)-BINAP.
Syntheses and radical scavenging activities of resveratrol derivatives
Lee, Hyun Jung,Seo, Jai Woong,Lee, Bong Ho,Chung, Kyoo-Hyun,Chi, Dae Yoon
, p. 463 - 466 (2007/10/03)
Nine new resveratrol derivatives, having bromo, iodo, and fluoroethyl groups, were designed and synthesized. All compounds having free phenol groups showed good free radical scavenging activity. Among them, 2-bromoresveratrol 19 has a similar free radical scavenging activity to (+)-catechin.
