676606-06-7

Upstream product

• 21085-72-3 1-bromo-2,3,4-tri-O-acetyl-α-D-glucuronic acid methyl ester 
• 53868-45-4 (Z)-2-(4'-methylphenyl)-3-N,N-dimethylaminopropenal 
• 676606-03-4 methyl 2,3,4-tri-O-acetyl-(2'-(4''-methylphenyl)-3'-oxo-1'-(E)-propenyloxy)-β-D-glucopyranosiduronate 

Downstream Products

• 676606-09-0 methyl 2,3,4-tri-O-acetyl-(2'-(4''-methylphenyl)-3'-(O-phenylcarbonyloxy)-1'-(E)-propenyloxy)-β-D-glucopyranosiduronate 

Relevant academic research and scientific papers

A new linker for glucuronylated anticancer prodrugs

The synthesis, enzymatic hydrolysis and self decomposition of model glucuronylated prodrugs, incorporating a new linker with different aryl substituents, have been studied. Determination of kinetic parameters (V max, Km and t1/2

A new spacer group derived from arylmalonaldehydes for glucuronylated prodrugs

A new glucuronylated prodrug of doxorubicin, potentially useful for ADEPT or PMT cancer chemotherapy, has been prepared from 4-methyl phenyl malonaldehyde. The enol ether spacer, linked via a carbamate to the 3'-amino group of doxorubicin is rapidly cleav