676622-21-2Relevant academic research and scientific papers
N-Arylalkylpiperidine urea derivatives as CC chemokine receptor-3 (CCR3) antagonists
Batt, Douglas G.,Houghton, Gregory C.,Roderick, John,Santella III, Joseph B.,Wacker, Dean A.,Welch, Patricia K.,Orlovsky, Yevgeniya I.,Wadman, Eric A.,Trzaskos, James M.,Davies, Paul,Decicco, Carl P.,Carter, Percy H.
, p. 787 - 791 (2007/10/03)
The synthesis and structure-activity relationships of N- arylalkylpiperidylmethyl ureas as antagonists of the CC chemokine receptor-3 (CCR3) are presented. These compounds displayed potent binding to the receptor as well as functional antagonism of eotaxin-elicited effects on eosinophils.
N-substituted heterocyclic amines as modulators of chemokine receptor activity
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Page/Page column 36-37, (2010/02/06)
The present application describes modulators of chemokine receptors of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.
