676630-83-4

Upstream product

• 74-88-4 methyl iodide 
• 115522-13-9 3-(3,4-dimethyl-phenyl)-2-oxo-propionic acid 

Downstream Products

• 676631-47-3 (E)-(S)-4-({(S)-2-[(R)-3-(3,4-Dimethyl-phenyl)-3-methyl-2-methylamino-butyrylamino]-3,3-dimethyl-butyryl}-methyl-amino)-2,5-dimethyl-hex-2-enoic acid ethyl ester 
• 676631-94-0 (E)-(S)-4-({(S)-2-[(S)-3-(3,4-Dimethyl-phenyl)-3-methyl-2-methylamino-butyrylamino]-3,3-dimethyl-butyryl}-methyl-amino)-2,5-dimethyl-hex-2-enoic acid ethyl ester 
• 676626-95-2 3-(3,4-dimethyl-phenyl)-3-methyl-2-methylamino-butyric acid 
• 676631-97-3 (E)-(S)-4-({(S)-2-[(S)-3-(3,4-Dimethyl-phenyl)-3-methyl-2-methylamino-butyrylamino]-3,3-dimethyl-butyryl}-methyl-amino)-2,5-dimethyl-hex-2-enoic acid 

Relevant academic research and scientific papers

Synthesis and activity of novel analogs of hemiasterlin as inhibitors of tubulin polymerization: Modification of the a segment

Analogs of HTI-286 (1), containing various aromatic rings in the A segment, were synthesized as potential inhibitors of tubulin polymerization, and the structure-activity relationships related to stereo- and regio-chemical effects of substituents on the a