67674-39-9

Usage

InChI:InChI=1/C12H19N/c1-12(2,3)11-6-4-10(5-7-11)8-9-13/h4,11H,5-8H2,1-3H3

Upstream product

• 98-54-4 para-tert-butylphenol 
• 372-09-8 cyanoacetic acid 
• 98-53-3 4-tercbutyl-cyclohexanone 
• 2537-48-6 diethyl 1-cyanomethylphosphonate 

Downstream Products

• 63089-64-5 2-(4-tert-butyl-1-cyclohexenyl)-2-methylpropiononitrile 

Relevant academic research and scientific papers

Pd-Catalyzed Remote Site-Selective and Stereoselective C(Alkenyl)-H Alkenylation of Unactivated Cycloalkenes

A palladium-catalyzed alkenylation involving remote δ-position C(alkenyl)-H activation of cycloalkenes reacting with electron-deficient alkenes is described. This method features excellent site selectivity and stereoselectivity to efficiently afford only E-selective highly substituted 1,3-diene derivatives with extra-ligand-free and good functional group tolerance including estrone and free N-H tryptamine under weakly alkaline conditions. Mechanistic studies suggest that picolinamide as a bidentate directing group enables the formation of unique alkenyl palladacycle intermediates.

A method of preparing P-tert-butyl benzyl cyanide

The invention discloses a method for preparing butylphenylacetonitrile, and the method is capable of preparing butylphenylacetonitrile by using p-tert-butylphenol as a raw material through catalyzing, hydrogenating, and condensation with Knoevenagel of cyanoacetic acid, and catalyzing dehydro-aromatization, wherein a small amount of ethylbenzene is added into the reaction mixture in the dehydro-aromatization catalyzing step, and meanwhile, as the technical means of introducing inert gas with a certain flow rate is adopted, the preparation method provided by the invention has industrial application value. Compared with the existing preparation method, the method provided by the invention has the advantages that the raw material is easy to get, the yield is high, the cost is low, isomers which are difficult to separate are not contained, highly toxic sodium cyanide and other highly toxic irritating ingredients are not used, the three wastes are less, the security is high and the like, so that the method provided by the invention is suitable for industrial production.

Cob(I)alamin Differentiating Alkenes During Saturation

The olefins 2, 7, 11, and 19 have been reduced using catalytic amounts of cob(I)alamin(1(I)).During a slow saturation, the catalyst is able to differentiate the two diastereotopic faces of the endocyclic double bonds in 11 (t1/2 40 d) and 19 (t1/2 80 d, cf.Scheme 4).The substrates 2 (t1/2 1 h, cf.Scheme 2) and 7 (t1/2 4 h, cf.Scheme 3) are reduced much faster.A rationalization of the data can be obtained formulating tertiary alkylcobalamins as intermediates.Of the oxime 6 ( cf.Scheme 2) and the p-bromobenzoate 23 (cf.Scheme 5) the structures have been determined by X-ray analysis.