67680-10-8

Basic information

• Product Name: tert-butyl benzeneselenyl sulfide
• Synonyms: tert-butyl benzeneselenyl sulfide
• CAS NO: 67680-10-8
• Molecular Weight: 245.247
• Mol File: 67680-10-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: tert-butyl benzeneselenyl sulfide(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl benzeneselenyl sulfide(67680-10-8)
• EPA Substance Registry System: tert-butyl benzeneselenyl sulfide(67680-10-8)

Safety Data

• Hazardous Substances Data: 67680-10-8(Hazardous Substances Data)

Upstream product

• 75272-63-8 selenium(II) bis(2-methyl-2-propanethiolate) 
• 591-51-5 phenyllithium 
• 645-96-5 Benzeneselenol 
• 75-66-1 2-methylpropan-2-thiol 
• 1666-13-3 diphenyl diselenide 
• 67680-11-9 S-tert-butyl benzenethioseleninate 
• 6996-92-5 benzeneseleninic acid 

Relevant articles and documents

The Induced Decomposition of S-tert-Butyl Benzenethioseleninate

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Thiol peroxidase activity of diaryl ditellurides as determined by a 1H NMR method

A 1H NMR method was developed for the assessment of the glutathione peroxidase-like activity of synthetic compounds. In this assay, thiols (N-acetylcysteine, tert-butyl mercaptan and 1-octyl mercaptan) were oxidized to the corresponding disulfides in CD3OD or CD3OD/D2O in the presence of hydrogen peroxide and the catalyst to be evaluated. The time required to reduce the thiol concentration with 50%, t50, was determined as a measure of the thiol peroxidase activity of the catalyst. Several diaryl ditellurides were efficient catalysts when present in low concentrations (0.3 mol %), whereas compounds with well-documented glutathione peroxidase-like activity in other assays were inactive (Ebselen, diaryl diselenides). The glutathione peroxidase-like activity of diaryl ditellurides was also assessed by using the classical coupled reductase assay. A mechanistic study showed that diaryl ditellurides, in the presence of hydrogen peroxide and a thiol, were rapidly converted to tellurosulfides. These species were stable enough to be isolated in some cases. The tellurosulfides reacted very slowly with added thiol, but in the presence of thiol/hydrogen peroxide the thiol was rapidly converted to its corresponding disulfide. On the basis of these observations, a mechanism involving a tellurinic acid thiol ester was proposed for the thiol peroxidase reaction of ditellurides. In contrast to tellurosulfides, selenosulfides, obtained either from diphenyl diselenide/hydrogen peroxide/1-octyl mercaptan or from Ebselen and 1-octyl mercaptan, were found to react very slowly with thiols in the presence of hydrogen peroxide.