67685-02-3

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 109-92-2 ethyl vinyl ether 
• 592-55-2 2-Bromoethyl ethyl ether 

Downstream Products

• 1618679-19-8 C₂₃H₂₇BF₂N₂O₂ 
• 350687-24-0 ethyl 3,4-dichloro-5-[5-(4-hydroxyphenyl)-1,3-oxazol-2-yl]-1H-pyrrole-2-carboxylate 
• 350687-26-2 3,4-dichloro-5-[5-(4-hydroxyphenyl)-1,3-oxazol-2-yl]-1H-pyrrole-2-carboxylic acid 
• 156280-93-2 2-(3,4-dichloro-1H-pyrrol-2-yl)-5-(4-hydroxyphenyl)-1,3-oxazole 

Relevant academic research and scientific papers

Total synthesis of phorbazole C

The first total synthesis of the marine natural product phorbazole C 1 occurring in the sea sponge Phorbas aff. clathrata is reported. In the key steps of the convergent approach the 3,4-dichloro-5-ethoxycarbonyl-pyrrole-2-carboxylic acid (4) forms an ami

Metalloporphyrin–indomethacin conjugates as new photosensitizers for photodynamic therapy

Photodynamic therapy (PDT) is a promising cancer treatment approach with the advantages of low toxicity and noninvasive characteristics. In this study, a series of metalloporphyrin–indomethacin conjugates tethered with poly(ethylene glycol) (PEG) chains w

Bodipy dyes bearing oligo(ethylene glycol) groups on the meso-phenyl ring: Tuneable solid-state photoluminescence and highly efficient OLEDs

Borondipyrromethene (Bodipy) dyes with strong solid-state photoluminescence are highly desirable for their applications in OLEDs. In this work, a series of meso-(4-R-C6H4)-substituted Bodipy dyes (R = H for B1; R = (OCH2CH2)nOCH2CH3, n = 0-3 for B2-B5, respectively) were prepared through an acid-catalyzed reaction. The flexible ether groups attached to the periphery of B2-B5 are expected to influence the molecular arrangement and intermolecular interactions in solid state. Crystallographic analysis of B1-B4 reveals that the meso-phenyl ring is almost orthogonal to the indacene plane. Intermolecular π-π interactions are observed in B1 but absent in B2-B4. As a consequence, the dye B1 is weakly emissive in solid state, while B2-B4 emit strongly in the red region with emission quantum yields of up to 0.33. The PMMA films doped with B2 show two separated emission peaks, and their relative intensity is concentration dependent, leading to the fluorescence color varying from greenish yellow to red as the concentrations successively increased from 5 to 80 wt%. The formation of dimers in the ground state is found to be responsible for the red emission in the condensed state. Efficient OLEDs were fabricated by doping 2 wt% B2-B4 as emitters and gave high luminance, current efficiency, and external quantum efficiency of up to 920 cd m-2, 8.00 cd A-1, and 2.15%, respectively. This journal is the Partner Organisations 2014.

Imidazole derivatives

The present invention relates to the imidazole derivative of the following formula (I) wherein R1 is hydrogen, optionally substituted alkyl and the like, R2 is hydrogen, optionally substituted alkyl and the like, R3is optionally substituted heteroaryl, R4 is optionally substituted cycloalkyl, optionally substituted phenyl and the like, provided that when R1 is hydrogen, and R2 and R4 are the same or different and each is phenyl or phenyl substituted by halogen atom, lower alkyl or lower alkoxy, R3 is benzothiazolyl or thiazolyl substituted by phenyl, the imidazole derivative of the following formula (XII) wherein R6 is optionally substituted phenyl or optionally substituted heteroaryl and R7 is substituted phenyl, and pharmaceutically acceptable salts thereof. The compounds of the formulas (I) and (XII) and pharmaceutically acceptable salts thereof of the present invention inhibit IL-4 and IL-5 production by Th2 cells and are effective for the prophylaxis and treatment of allergic diseases such as atopic dermatitis, bronchial asthma, allergic rhinitis and the like.