67686-02-6

Usage

Uses

Used in Pharmaceutical Industry:
CHEMBRDG-BB 4010734 is used as a chemical intermediate for the synthesis of various drugs and pharmaceutical agents. Its potential biological activity and pharmacological effects make it a valuable compound in the development of new medications and therapies. Further research and testing are needed to explore its full potential and possible applications in the pharmaceutical field.

InChI:InChI=1/C14H21NO/c16-12-14-7-10-15(11-8-14)9-6-13-4-2-1-3-5-13/h1-5,14,16H,6-12H2

Upstream product

• 24228-41-9 1-(phenylethyl)-4-(ethoxycarbonyl)piperidine 
• 1126-09-6 4-carbethoxypiperidine 

Downstream Products

• 1207339-87-4 2-isopropyl-4-[[1-(2-phenylethyl)-4-piperidinyl]methoxy]-2Hpyrrolo[3,4-c]quinoline 
• 1207339-85-2 4-{[1-(2-phenyl)ethylpiperidine-4-yl]methoxy}-2-methyl-2H-pyrrolo[3,4-c]quinoline 

Relevant academic research and scientific papers

COMPOUND WITH SEROTONINERGIC ACTIVITY, PROCESS FOR PREPARING IT AND PHARMACEUTICAL COMPOSITION COMPRISING IT

Compound of formula (I) in which R1, R2 and R3 are defined in the following description, and the pharmaceutically acceptable acid-addition or base-addition salts thereof. The invention also relates to a process and an intermediate for preparing it, and to a pharmaceutical composition comprising it. The invention also relates to the use of a novel 2H-pyrrolo[3,4-c]quinoline compound for preparing a pharmaceutical composition that is active in the treatment of disturbances of the serotoninergic system.

Structure-activity relationship studies of novel 4-[2-[bis(4- fluorophenyl)methoxy]ethyl]-1-(3-phenylpropyl)piperidine analogs: Synthesis and biological evaluation at the dopamine and serotonin transporter sites

Several analogs of the potent dopamine (DA) transporter ligand 4-[2- [bis(4-fluorophenyl)-methoxy]ethyl]-1-(3-phenylpropyl)piperidine, 1b, were made and biologically evaluated for their binding at the DA and serotonin (5HT) transporters in rat striatal membranes. Different alkyl chain lengths and substitutions were introduced in these molecules to generate an optimum activity and selectivity for the DA transporter. In general, unsubstituted and fluoro-substituted compounds were the most active and selective for the DA transporter. The compound 4-[2(diphenylmethoxy)ethyl]-1-benzylpiperidine, 9a, showed high potency and was the most selective for the DA transporter (5HT/DA = 49) in this series of compounds. Some of these novel analogs were found to be more selective in binding at the DA transporter than the original GBR 12909 molecule, 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3- phenylpropyl)piperidine.