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Nsc240911, also known as WZ4003, is a selective and potent inhibitor of atypical protein kinase C (aPKC) isoforms, specifically targeting aPKCι and aPKCζ. It has demonstrated the ability to induce apoptosis in cancer cells with elevated aPKC activity and has shown efficacy in inhibiting the growth of various cancer cell lines, including breast, prostate, and colon cancer. Nsc240911 is a promising chemical compound with potential therapeutic applications in cancer treatment.

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  • 67686-06-0 Structure
  • Basic information

    1. Product Name: Nsc240911
    2. Synonyms: Nsc240911;(1-Methyl-piperidin-4-yl)-acetic acidhydrochloride;1-Methyl-4-piperidineacetic acid HCl;2-(1-methylpiperidin-4-yl)acetic acid hydrochloride;(1-Methyl-piperidin-4-yl)-acetic acid x HCl, 98%
    3. CAS NO:67686-06-0
    4. Molecular Formula: C8H15NO2.ClH
    5. Molecular Weight: 193.672
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 67686-06-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: Nsc240911(CAS DataBase Reference)
    10. NIST Chemistry Reference: Nsc240911(67686-06-0)
    11. EPA Substance Registry System: Nsc240911(67686-06-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 67686-06-0(Hazardous Substances Data)

67686-06-0 Usage

Uses

Used in Cancer Treatment:
Nsc240911 is used as an anticancer agent for its ability to selectively inhibit aPKCι and aPKCζ, leading to the induction of apoptosis in cancer cells with elevated aPKC activity. This selective inhibition has demonstrated efficacy in inhibiting the growth of various cancer cell lines, such as breast, prostate, and colon cancer.
Used in Combination Therapy:
Nsc240911 is used in combination therapy with other cancer treatments to enhance the overall therapeutic effect. Its potential in combination therapy has shown promising results in preclinical studies, suggesting that it may improve the efficacy of existing cancer treatments and provide new options for patients with resistant or advanced cancers.
Used in Pharmaceutical Research:
Nsc240911 is used as a research tool in the development of new cancer therapies. Its selective inhibition of aPKC isoforms and its demonstrated efficacy in inducing apoptosis in cancer cells make it a valuable compound for studying the role of aPKC in cancer progression and identifying potential targets for novel therapeutic interventions.
Used in Drug Development:
Nsc240911 is used in the development of new drugs targeting aPKC isoforms in cancer treatment. Its promising results in preclinical studies and its potential in combination therapy make it a candidate for further investigation and optimization to develop more effective and targeted cancer treatments.

Check Digit Verification of cas no

The CAS Registry Mumber 67686-06-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,7,6,8 and 6 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 67686-06:
(7*6)+(6*7)+(5*6)+(4*8)+(3*6)+(2*0)+(1*6)=170
170 % 10 = 0
So 67686-06-0 is a valid CAS Registry Number.

67686-06-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(1-methylpiperidin-4-yl)acetic acid,hydrochloride

1.2 Other means of identification

Product number -
Other names 1-Methyl-4-piperidineacetic acid HCl

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:67686-06-0 SDS

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