677008-29-6Relevant academic research and scientific papers
Synthesis of [11C]/(13C)amines via carbonylation followed by reductive animation
Rahman, Obaidur,Kihlberg, Tor,Langstroem, Bengt
, p. 1612 - 1616 (2004)
Twelve 11C-labelled amines were prepared via 11C-carbonylation followed by reductive amination. The 11C-carbonylation was performed in the presence of tetrakis(triphenylphosphine)palladium using aryl iodides or aryl trifla
Synthesis of 11C-/13C-Ketones by Suzuki Coupling
Rahman, Obaidur,Kihlberg, Tor,Langstroem, Bengt
, p. 474 - 478 (2007/10/03)
Aryl triflates, methyl- or arylboronic acids, and a low concentration of [11C]carbon monoxide were employed on small scale in the syntheses of fifteen 11C-labelled ketones using palladium-mediated Suzuki coupling reactions. The reagents were confined in a micro-autoclave and heated at 150 °C for 5 min. The reaction required the presence of LiBr, but no additional base. The 11C-labelled products were obtained with decay-corrected radiochemical yields in the range 10-70% and with high specific radioactivity (150-640 GBq/μmol). The radiochemical purity of the final products exceeded 98%. One 13C-substituted ketone ([ 13C]-2′-benzonaphthone) was prepared and analysed by NMR spectroscopy for confirmation of the labelling position. The reference compound 2′-benzonaphthone was prepared by a palladium-catalysed reaction between sodium tetraphenylborate and 2-naphthoyl chloride. 2-Thienyl p-tolyl ketone, 4-nitrophenyl 2-thienyl ketone and 2-naphthyl 2-thienyl ketone were prepared by reactions between thiophene-2-boronic acid and the corresponding acid chlorides. The presented approach is novel and seems to be an efficient method for the synthesis of a wide range of 11C- as well as 13C-labelled ketones. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.
