677009-98-2Relevant academic research and scientific papers
A versatile approach for the asymmetric synthesis of 3-alkyl-2,3-dihydro- 1H-isoindolin-1-ones
Chen, Ming-De,Zhou, Xiang,He, Ming-Zhu,Ruan, Yuan-Ping,Huang, Pei-Qiang
, p. 1651 - 1657 (2007/10/03)
Based on the use of (R)-p-benzyloxyphenylglycinol (10) as a new oxidatively cleavable chiral auxiliary, a flexible approach to (R)-3-alkyl-2,3-dihydro-1H-isoindolin-1-ones via a diastereoselective reductive-alkylation is developed. The oxidative cleavage of the chiral auxiliary by CAN under mild conditions ensured the access to (R)-3-alkyl-2,3-dihydro-1H-isoindolin-1-ones with ee at least 92%.
