67708-22-9

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InChI:InChI=1/C5H6N4O5/c10-1-4(13)5(14,8-2(11)6-1)9-3(12)7-4/h13-14H,(H2,7,9,12)(H2,6,8,10,11)

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• 69-93-2 uric Acid 

Relevant academic research and scientific papers

METAL-ORGANIC FRAMEWORKS FOR ELECTROCHEMICAL DETECTION OF ANALYTES

In some embodiments, the present disclosure pertains to methods of detecting an analyte in a sample by associating the sample with an electrode that includes a metal-organic framework. After association, the redox properties of the electrode are evaluated. Thereafter, the presence or absence of the analyte in the sample is detected by correlating the redox properties of the electrode to the presence or absence of the analyte. In some embodiments, the present disclosure pertains to electrodes that include a metal-organic framework and an electrode surface. In particular embodiments of the present disclosure, the metal-organic framework is associated with the electrode surface. Additional embodiments of the present disclosure pertain to methods of making the electrodes of the present disclosure by associating a metal-organic framework with an electrode surface. In some embodiments, the methods of the present disclosure also include a step of mixing the metal-organic framework with a polymer.

Simultaneous voltammetric detection of six biomolecules using a nanocomposite of titanium dioxide nanorods with multi-walled carbon nanotubes

In this proof-of-concept study, a novel nanocomposite of titanium dioxide nanorods with multi-walled carbon nanotubes (TiO2NRs-MWCNTs) was synthesized using a solvo-thermal method and characterized by transmission electron microscopy (TEM) and Fourier-transform infrared spectroscopy (FTIR). The nanocomposite of TiO2NRs-MWCNTs was utilized to modify the surface of a glassy carbon electrode (GCE) using 1.5% (v/v) Nafion solution for a proof-of-concept study to detect uric acid (UA), xanthine (XA), theophylline (TP) and theobromine (TB) in the presence of ascorbic acid (AA) and dopamine (DA). Simultaneous detection of these six biomolecules was performed using differential pulse voltammetry (DPV) in a wide potential window from -0.3 V to -1.6 V (vs. Ag/AgCl) at pH 4.0. The TiO2NRs-MWCNTs/GCE showed strong, stable and six simultaneous well-separated anodic peaks at 0.13, 0.35, 0.50, 0.85, 1.10 and 1.28 V for AA, DA, UA, XA, TP and TB, respectively. The calibration curves showed linearity to 191.0, 147.0, 537.0, 586.0, 893.0, 1653.0 μM with detection limits of 0.51, 0.06, 0.05, 0.09, 0.56 and 0.75 μM for AA, DA, UA, XA, TP and TB, respectively. The electrochemical performance of the TiO2NRs-MWCNTs/GCE displayed good reproducibility for simultaneous determination of six analytes. Finally, our preliminary results suggested that the TiO2NRs-MWCNTs/GCE can provide a promising platform for rapid quantitative detection of AA, DA, UA, XA, TP and TB in quality control studies of real samples such as pharmaceuticals and food products.

Simultaneous determination of ascorbic acid, dopamine, uric acid, and tryptophan by nanocrystalline ZSM-5 modified electrodes

Nanocrystalline ZSM-5 was prepared by using propyltriethoxysilane as an additive in the conventional ZSM-5 synthesis composition. Materials were characterized by a complementary combination of X-ray diffraction, nitrogen sorption, and Scanning electron microscopy. Transition metal ion exchanged nanocrystalline ZSM-5 (M-Nano-ZSM-5, where M = Cu2+, Ni2+, Co2+, Fe2+, and Mn2+) modified electrodes were constructed for the simultaneous determination of ascorbic acid (AA), dopamine (DA), uric acid (UA), and tryptophan (Trp). Electrochemical studies were carried out by using cyclic voltammetry, linear sweep voltammetry, and chronoamperometry in buffer solution at pH 3.5. Fe-Nano-ZSM-5 modified electrode exhibited excellent electrocatalytic activity with wellseparated oxidation peaks towards AA, DA, UA, and Trp in their simultaneous determination. Among the M-Nano-ZSM-5 and transition metal ion-exchanged ZSM-5 (M-ZSM-5) materials investigated in this study, Fe-Nano-ZSM-5 exhibited the highest catalytic activities towards the oxidation of AA, DA, UA, and Trp with good stability, sensitivity, and selectivity. The analytical performance of this sensor was demonstrated for the simultaneous determination of AA, DA, UA, and Trp in blood serum and UA concentration in urine samples.

pH dependent photooxygenation of xanthine and uric acid

Photooxygenation of xanthine and uric acid has been carried out by singlet oxygen in presence of methylene blue and rose bengal respectively in different media (neutral, acidic, alkaline) at different pH giving various products, which have been characterized by spectral data and elemental analysis.

Voltammetric resolution of dopamine in the presence of ascorbic acid and uric acid at poly (calmagite) film coated carbon paste electrode

The poly (calmagite) film was synthesized on the surface of carbon paste electrode by electrochemical method. The synthesized polymer film coated electrode exhibits excellent electrocatalytic activity towards the detection of dopamine at neutral pH. The scan rate effect was found to be adsorption controlled electrode process. The concentration effect of dopamine was studied. The redox peak potentials of dopamine were depend on pH. This polymer film coated electrode was very good at simultaneous study of dopamine in the presence of high concentrated ascorbic acid and uric acid. The incorporation study was done by varying the concentration of one species while other two are kept constant. The proposed method was applied to the detection of dopamine in injection samples.