677297-30-2Relevant academic research and scientific papers
Discovery of 3,3′-(2,4-diaminopteridine-6,7-diyl)diphenol as an isozyme-selective inhibitor of PI3K for the treatment of ischemia reperfusion injury associated with myocardial infarction
Palanki, Moorthy S. S.,Dneprovskaia, Elena,Doukas, John,Fine, Richard M.,Hood, John,Kang, Xinshan,Lohse, Dan,Martin, Michael,Noronha, Glenn,Soll, Richard M.,Wrasidlo, Wolfgang,Yee, Shiyin,Zhu, Hong
, p. 4279 - 4294 (2007)
In studies aimed toward identifying effective and safe inhibitors of kinase signaling cascades that underlie ischemia/reperfusion (I/R) injury, we synthesized a series of pteridines and pyridopyrazines. The design strategy was inspired by the examination
Vasculostatic agents and methods of use thereof
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, (2008/06/13)
Compositions and methods and are provided for treating disorders associated with compromised vasculostasis. Invention methods and compositions are useful for treating a variety of disorders including for example, stroke, myocardial infarction, cancer, ischemia/reperfusion injury, autoimmune diseases such as rheumatoid arthritis, eye diseases such as retinopathies or macular degeneration or other vitreoretinal diseases, inflammatory diseases, vascular leakage syndrome, edema, transplant rejection, adult/acute respiratory distress syndrome (ARDS), and the like.
