677304-83-5

Usage

Uses

Used in Pharmaceutical Industry:
7-Benzothiazolecarboxylic acid (9CI) is used as a chemical intermediate for the synthesis of pyrazole inhibitors of coactivator associated arginine methyltransferase 1 (CARM1). These inhibitors play a crucial role in regulating gene expression and have potential therapeutic applications in treating various diseases.
Additionally, 7-Benzothiazolecarboxylic acid (9CI) is utilized in the preparation of aminofuro-pyridine derivatives, which act as inhibitors of TAK1 (Transforming Growth Factor-β Activated Kinase 1). TAK1 inhibition can modulate inflammatory and immune responses, making these derivatives valuable in the development of treatments for inflammatory and autoimmune disorders.

InChI:InChI=1/C8H5NO2S/c10-8(11)5-2-1-3-6-7(5)12-4-9-6/h1-4H,(H,10,11)

Upstream product

• 192948-00-8 methyl 3-thioureidobenzoate 
• 1038509-28-2 methyl benzo[d]thiazole-7-carboxylate 
• 677304-90-4 ethyl 1,3-benzothiazole-7-carboxylate 
• 209459-11-0 methyl 2-aminobenzo[d]thiazole-7-carboxylate 
• 4518-10-9 Methyl 3-aminobenzoate 

Relevant academic research and scientific papers

2-AZA-BICYCLO[2.2.1]HEPTANE DERIVATIVES

The invention relates to novel 2-aza-bicyclo[2.2.1]heptane derivatives of formula (I), wherein A, B, n and R1 are as described in the description, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as m

2-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES

The invention relates to novel 2-aza-bicyclo[3.1.0]hexane derivatives of Formula (I) wherein A, B, n and R1 are as described in the description, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as medicaments, especially as orexin receptor antagonists.

INDAZOLES, BENZOTHIAZOLES, BENZOISOTHIAZOLES, BENZISOXAZOLES, AND PREPARATION AND USES THEREOF

The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nACh receptors), activation of nACh receptors, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (e.g., indazoles and benzothiazoles), which act as ligands for the α7 nACh receptor subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

INDAZOLES, BENZOTHIAZOLES, AND BENZOISOTHIAZOLES, AND PREPARATION AND USES THEREOF

The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (indazoles and benzothiazoles), which act as ligands for the α7 nAChR subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.