677323-01-2Relevant articles and documents
Arylphthalazines: Identification of a new phthalazine chemotype as inhibitors of VEGFR kinase
Piatnitski, Evgueni L.,Duncton, Matthew A. J.,Kiselyov, Alexander S.,Katoch-Rouse, Reeti,Sherman, Dan,Milligan, Daniel L.,Balagtas, Chris,Wong, Wai C.,Kawakami, Joel,Doody, Jacqueline F.
, p. 4696 - 4698 (2005)
A novel class of 4-arylamino-phthalazin-1-yl-benzamides is described as inhibitors of vascular endothelial growth factor receptor II (VEGFR-2). Several compounds display potent VEGFR-2 inhibitory activity with an IC50 as low as 0.078 μM in an H
Synthesis and biological activity of aminophthalazines and aminopyridazines as novel inhibitors of PGE2 production in cells
Medda, Federico,Sells, Earlphia,Chang, Hui-Hua,Dietrich, Justin,Chappeta, Shashi,Smith, Breland,Gokhale, Vijay,Meuillet, Emmanuelle J.,Hulme, Christopher
, p. 528 - 531 (2013/02/25)
This Letter reports the synthesis and biological evaluation of a collection of aminophthalazines as a novel class of compounds capable of reducing production of PGE2 in HCA-7 human adenocarcinoma cells. A total of 28 analogs were synthesized, a