677323-85-2Relevant academic research and scientific papers
Structure-Based Optimization of Novel Azepane Derivatives as PKB Inhibitors
Breitenlechner, Christine B.,Wegge, Thomas,Berillon, Laurent,Graul, Klaus,Marzenell, Klaus,Friebe, Walter-Gunar,Thomas, Ulrike,Schumacher, Ralf,Huber, Robert,Engh, Richard A.,Masjost, Birgit
, p. 1375 - 1390 (2007/10/03)
Novel azepane derivatives were prepared and evaluated for protein kinase B (PKB-α) and protein kinase A (PKA) inhibition. The original (-)-balanol-derived lead structure (4R)-4-(2-fluoro-6-hydroxy-3-methoxy-benzoyl)-benzoic acid (3R)-3-[(pyridine-4-carbon
