677323-93-2

Upstream product

• 602277-73-6 (3R,4S)-4-methanesulfonyloxy-3-[(pyridine-4-carbonyl)amino]azepane-1-carboxylic acid tert-butyl ester 
• 602277-72-5 (3R,4R)-4-azido-3-[(pyridine-4-carbonyl)amino]azepane-1-carboxylic acid tert-butyl ester 
• 602277-74-7 (3R,4S)-4-hydroxy-3-[(pyridine-4-carbonyl)amino]azepane-1-carboxylic acid tert-butyl ester 
• 602277-71-4 (3R,4R)-4-amino-3-[(pyridine-4-carbonyl)amino]azepane-1-carboxylic acid tert-butyl ester 
• 677323-83-0 4-[(2-fluoro-3-methoxy-6-methoxymethoxy-phenyl)-hydroxy-methyl]-benzoicacidmethylester 
• 677323-90-9 (2-fluoro-3-methoxy-6-methoxymethoxyphenyl)-(4-hydroxymethylphenyl)methanol 
• 677323-91-0 (2-fluoro-3-methoxy-6-methoxymethoxybenzoyl)benzaldehyde 
• 198419-20-4 (3R,4S)-3-Amino-4-hydroxy-azepane-1-carboxylic acid tert-butyl ester 
• 55-22-1 pyridine-4-carboxylic acid 

Relevant academic research and scientific papers

Structure-Based Optimization of Novel Azepane Derivatives as PKB Inhibitors

Novel azepane derivatives were prepared and evaluated for protein kinase B (PKB-α) and protein kinase A (PKA) inhibition. The original (-)-balanol-derived lead structure (4R)-4-(2-fluoro-6-hydroxy-3-methoxy-benzoyl)-benzoic acid (3R)-3-[(pyridine-4-carbon