677350-30-0Relevant academic research and scientific papers
Conjugates of betulin derivatives with AZT as potent anti-HIV agents
Xiong, Juan,Kashiwada, Yoshiki,Chen, Chin-Ho,Qian, Keduo,Morris-Natschke, Susan L.,Lee, Kuo-Hsiung,Takaishi, Yoshihisa
experimental part, p. 6451 - 6469 (2010/10/18)
Fourteen novel conjugates of 3,28-di-O-acylbetulins with AZT were prepared as anti-HIV agents, based on our previously reported potent anti-HIV triterpene leads, including 3-O-acyl and 3,28-di-O-acylbetulins. Nine of the conjugates (49-53, 55, 56, 59, and
3-O-Glutaryl-dihydrobetulin and related monoacyl derivatives as potent anti-HIV agents
Kashiwada, Yoshiki,Sekiya, Michiko,Ikeshiro, Yasumasa,Fujioka, Toshihiro,Kilgore, Nicole R.,Wild, Carl T.,Allaway, Graham P.,Lee, Kuo-Hsiung
, p. 5851 - 5853 (2007/10/03)
3-O-Glutaryl-dihydrobetulin (17) demonstrated extremely potent anti-HIV activity with an EC50 value of 2 × 10-5 μM and a TI value of 1.12 × 106. 3-O-(3′,3′- Dimethylsuccinyl)- and 3-O-(3′,3′-dimethylglutaryl)-dihydrobetulins (15, 16) were also potent anti-HIV compounds with EC50 values of 0.0017 and 0.0013 μM, respectively, and TI values of 16,160 and 19,530, respectively. 3-O-Acyl-betulin and -dihydrobetulin derivatives were prepared and evaluated for anti-HIV activity. 3-O-Glutaryl-dihydrobetulin (17) demonstrated extremely potent anti-HIV activity with an EC50 value of 2 × 10-5 μM and a TI value of 1.12 × 106. 3-O-(3′,3′-Dimethylsuccinyl)- and 3-O-(3′,3′- dimethylglutaryl)-dihydrobetulins (15, 16) were also potent anti-HIV compounds with EC50 values of 0.0017 and 0.0013 μM, respectively, and TI values of 16,160 and 19,530, respectively.
