677352-33-9Relevant academic research and scientific papers
Diastereo- and Enantioselective Synthesis of Novel β-Lactam-Containing 1,4-Benzodiazepines through a Ketene-Imine Cycloaddition Reaction
Pozo, Carlos del,Macias, Alberto,Lopez-Ortiz, Fernando,Maestro, Miguel Angel,Alonso, Eduardo,Gonzalez, Javier
, p. 535 - 545 (2007/10/03)
Novel tricyclic scaffolds that incorporate a β-lactam ring fused to the d bond of a 1,4-benzodiazepine seven-membered ring have been synthesized in a process that constitutes one of the few examples of Staudinger-type reactions involving ketimines described so far. In addition the creation of an asymmetric quaternary center has been achieved. The combination of these two "privileged structures" in a single compound is bound to confer interesting biological properties upon them.
