67739-37-1Relevant academic research and scientific papers
Synthesis of 13C-Labeled Pyrazinone Thrombin Inhibitors and Elucidation of Metabolic Activation Pathways
Ho, Jonathan Z.,Braun, Matthew P.,Subramanian, Raju,Gao, Ying-Duo,Dean, Dennis C.,Melillo, David G.
, p. 674 - 681 (2004)
In support of a research program aimed at discovering orally bioavailable thrombin inhibitors, 13C-labeled 3-aminopyrazinone acetamide thrombin inhibitors have been prepared to aid in the structural elucidation of key metabolites during preclin
Synthesis and evaluation of ketophosph(on)ates as β-lactamase inhibitors
Perumal, Senthil K.,Pratt
, p. 4778 - 4785 (2007/10/03)
A series of amidoketophosph(on)ates of general structure PhCH 2OCONHCH(R)COCHR′(CH2)n(O)P-(O 2-)(O)R″ (R = H, CH3; R′ = H, CH3; n = 0, 1; R″ = H, CH3, Et, Ph) have bee
Direct observation of intramolecular hydrogen bonds in peptide 3 10 helices by 3hJN,C′ scalar couplings
Bellanda, Massimo,Rainaldi, Mario,Broxterman, Quirinus B.,Kaptein, Bernard,Formaggio, Fernando,Crisma, Marco,Mammi, Stefano,Toniolo, Claudio
, p. 3152 - 3155 (2007/10/03)
Differentiating helices: The direct observation of hydrogen bonds by 3hJN,C′ scalar couplings (see picture) is not only possible for α-helix and β-sheet peptides and proteins, but for 310-helical peptides as well. The meth
