67759-68-6Relevant academic research and scientific papers
LiBr-Catalyzed C3-Disulfuration between Indole and N-Dithiophthalimide
Li, Wangyu,Pan, Yuanjiang,Shi, Keqiang,Wang, Dungai
, (2022/02/07)
A simple, green halide-catalyzed protocol for disulfuration of indole derivatives with N-dithiophthalimides has been developed. This C-H disulfide reaction proceeded smoothly at room temperature with economical LiBr as catalyst, providing an effective method for the synthesis of novel unsymmetrical disulfides. A series of 3-dithioindole derivatives were obtained in high yields with good functional group tolerance; moreover, the wide scope of Harpp reagents (aryl, benzyl, primary, secondary, tertiary) confirmed the practicability of this approach.
