67761-47-1

Upstream product

• 766-96-1 4-bromo-1-ethynylbenzene 
• 1608-42-0 benzenedizolium-2-carboxylate 
• 94275-22-6 5,11-dibromo-5,6,11,12-tetrahydrodibenzo[a,e]cyclooctadiene 
• 100-58-3 phenylmagnesium bromide 
• 96378-64-2 5-Phenyl-6-(4-brom-phenyl)-dibenzocyclooctatetraen 
• 97083-18-6 5,6-Bis-(4-brom-phenyl)-dibenzocyclooctatetraen 
• 33416-97-6 5,6-Diphenyl-dibenzocyclooctatetraen 

Downstream Products

• 1687-94-1 5,10-diphenyldibenzopentalene 

Relevant academic research and scientific papers

Control of Enantioselectivity in Rhodium(I) Catalysis by Planar Chiral Dibenzo[a,e]cyclooctatetraenes

Planar chiral 5,11-disubstiuted dibenzo[a,e]cyclo-octatetraenes (dbCOTs) have been developed as the first useful chiral homologs to dbCOT-ligands for asymmetric applications. Methods enabling the preparation of such compounds on a gram-scale in enantiomerically pure form are described. Evaluated as ligands in rhodium(I)-catalyzed 1,4- and 1,2-arylation reactions, tertiary and quarternary stereogenic centers were formed with excellent yields and selectivities of up to >99 % ee. A catalytic asymmetric synthesis of a key cyclization precursor to (?)-penifulvin A highlights the system in an applied context.