67763-96-6

Basic information

• Product Name: HUMAN IGF-I
• Synonyms: IGF-1R active human;Insulin-like Growth Factor-I from mouse;IGF-I (E3R);Insulin-like Growth Factor-I (E3R) human;sulfationfactorc;IGF-1 HUMAN;IGF-A, HUMAN;IGF-I
• CAS NO: 67763-96-6
• Molecular Weight: 0
• Product Categories: Peptides
• Mol File: 67763-96-6.mol
• Article Data: 0

Chemical Properties

• Appearance: /powder
• Storage Temp.: 2-8°C
• CAS DataBase Reference: HUMAN IGF-I(CAS DataBase Reference)
• NIST Chemistry Reference: HUMAN IGF-I(67763-96-6)
• EPA Substance Registry System: HUMAN IGF-I(67763-96-6)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 67763-96-6(Hazardous Substances Data)

Usage

Description

HUMAN IGF-I, also known as insulin-like growth factor I, is a growth hormone that plays a crucial role in cell growth, proliferation, and differentiation. It rapidly stimulates the phosphorylation on tyrosine of a 160 kDa cytosolic protein (pp160) in intact 3T3-L1 adipocytes. HUMAN IGF-I is a promising candidate for various applications in different industries due to its ability to promote growth and development.

Uses

Used in Cell Culture Applications:
HUMAN IGF-I is used as a media supplement for mouse embryonic fibroblasts culture, promoting cell growth and proliferation. It is essential for maintaining the viability and functionality of these cells in vitro.
Used in Pharmaceutical Research:
HUMAN IGF-I is used as a positive control to investigate the effects of various compounds, such as Angelica sinensis, on myotubes. This helps researchers understand the mechanisms of action and potential therapeutic benefits of these compounds.
Used in Growth Factor Cocktail Preparation:
HUMAN IGF-I is incorporated into growth factor cocktails, which are used to enhance the growth and differentiation of various cell types in culture. These cocktails are essential for studying cellular processes and developing new therapeutic strategies.

Biochem/physiol Actions

The IGFs (insulin like growth factors) are mitogenic polypeptide growth factors that stimulate the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro. IGF1 is an essential component for embryonic and postnatal skeletal development. Absence of IGF1 in mice negatively affects bone development, causes hypomineralization of skeletons and growth plate disturbances. It is also associated with cancer progression. It can suppress cell death and provides resistance to chemotherapy as well as radiation therapy.

Clinical Use

Protein of rDNA origin that has orphan drug status and is used in treating major burns requiring hospitalization.