6777-06-6

Basic information

• Product Name: 1-cyclohexylhydantoin
• Synonyms: 1-cyclohexylhydantoin
• CAS NO: 6777-06-6
• Molecular Weight: 182.222
• Mol File: 6777-06-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-cyclohexylhydantoin(CAS DataBase Reference)
• NIST Chemistry Reference: 1-cyclohexylhydantoin(6777-06-6)
• EPA Substance Registry System: 1-cyclohexylhydantoin(6777-06-6)

Safety Data

• Hazardous Substances Data: 6777-06-6(Hazardous Substances Data)

Upstream product

• 590-28-3 potassium cyanate 
• 87486-27-9 2-cyclohexylaminoacetonitrile hydrochloride 
• 1034186-46-3 methyl N-cyano-N-cyclohexylaminoacetate 
• 131543-46-9 Glyoxal 
• 698-90-8 N'-cyclohexylurea 

Relevant articles and documents

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An efficient approach for the synthesis of N-1 substituted hydantoins

An efficient three-step route for the synthesis of N-1 alkyl/aryl- substituted hydantoins was developed from inexpensive commercially available substrates. The reaction of amines with cyanogen bromide takes place to give monoalkyl/aryl cyanamides. This on treatment with methyl bromoacetate in the presence of sodium hydride in tetrahydrofuran affords methyl N-cyano-N-alkyl/arylaminoacetate, which undergoes hydrolysis and cyclization in the presence of 50% H2SO4 to afford N-1 substituted hydantoins in very good-to-excellent yields. Wide varieties of final products having primary, secondary, tertiary, and aryl substituents at the N-1 position were successfully synthesized by this method. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.