6777-71-5Relevant academic research and scientific papers
Cyclic dipeptide enantiomers
-
, (2008/06/13)
The invention provides novel cyclic dipeptide enantiomers comprising (R)-histidine or a derivative thereof as one of the amino acid residues. These compounds are useful a catalysts for production of (S) -α--cyanomethyl alcohols from aldehydes.
Asymmetric Addition of Hydrogen Cyanide to Substituted Benzaldehydes Catalyzed by a Synthetic Cyclic Peptide, Cyclo((S)-phenylalanyl-(S)-histidyl)
Kobayashi, Yoshiyuki,Asada, Shoichi,Watanabe, Ichigen,Hayashi, Hiroaki,Motoo, Yoshiyuki,Inoue, Shohei
, p. 893 - 896 (2007/10/02)
Using cyclo((S)-phenylalanyl-(S)-histidyl) as catalyst, optically active cyanohydrins from substituted benzaldehydes with p-methyl, m-methyl, o-methyl, m-methoxyl, or m-phenoxyl group were obtained with optical yield of 82-33percent.For the asymmetric cyanohydrin synthesis, nonpolar solvent such as benzene or carbon tetrachloride was advantageous, while on asymmetric synthesis took place in methanol or dimethyl sulfoxide.
