677702-36-2

Basic information

• Product Name: 5-NITRO INDAZOLE CARBOXALDEHYDE
• Synonyms: 5-NITRO-3-(1H)INDAZOLE CARBOXALDEHYDE;5-NITRO INDAZOLE CARBOXALDEHYDE;5-Nitro-3-(1H)indazolecarboxyaldehyde;5-NITROINDAZOLE-3-CARBOXYALDEHYDE;5-Nitro-1H-indazole-3-carbaldehyde;3-Formyl-5-nitro-1H-indazole;5-Nitro-1H-indazole-3-carboxaldehyde;1H-Indazole-3-carboxaldehyde, 5-nitro-
• CAS NO: 677702-36-2
• Molecular Formula: C₈H₅N₃O₃
• Molecular Weight: 191.14
• Mol File: 677702-36-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 300℃
• Boiling Point: 463.463 °C at 760 mmHg
• Flash Point: 234.094 °C
• Appearance: /
• Density: 1.612 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.783
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 9.75±0.40(Predicted)
• CAS DataBase Reference: 5-NITRO INDAZOLE CARBOXALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-NITRO INDAZOLE CARBOXALDEHYDE(677702-36-2)
• EPA Substance Registry System: 5-NITRO INDAZOLE CARBOXALDEHYDE(677702-36-2)

Safety Data

• Safety Statements: S24/25:
• Hazardous Substances Data: 677702-36-2(Hazardous Substances Data)

Usage

General Description

5-Nitro indazole carboxaldehyde is a chemical compound containing a nitro group and an aldehyde group. It is commonly used in organic synthesis and medicinal chemistry research. 5-Nitro indazole carboxaldehyde has been found to exhibit bactericidal activity against certain strains of bacteria and has also been investigated for its potential as an antitumor agent. Additionally, 5-Nitro indazole carboxaldehyde has been studied for its ability to inhibit the growth of certain parasitic organisms. Its unique structure and reactivity make it a valuable building block in the development of new pharmaceuticals and agrochemicals. However, it is important to handle this compound with care due to its potential health hazards and toxicity.

InChI:InChI=1/C8H5N3O3/c12-4-8-6-3-5(11(13)14)1-2-7(6)9-10-8/h1-4H,(H,9,10)

Upstream product

• 6146-52-7 5-nitroindole 
• 68-12-2 N,N-dimethyl-formamide 
• 5401-94-5 5-nitroindazole 

Downstream Products

• 677702-37-3 5-Nitro-1-(2,4,6-trimethylbenzenesulphonyl)-1H-indazole-3-carbaldehyde 
• 78155-75-6 methyl 5-nitro-1H-indazole-3-carboxylate 

Relevant articles and documents

Synthesis, antitumor evaluation, and molecular docking studies of indole–indazolyl hydrazide–hydrazone derivatives

Abstract: A series of ten novel hydrazide–hydrazones linked indole and indazole moieties were designed and synthesized. All the synthesized compounds were evaluated for their cytotoxicity against four human cancer cell lines (HeLa, MDA-MB-231, MCF-7, and A549). Three of the synthesized compounds showed promising cytotoxicity specifically on some of the tested cell lines with IC50 values ranging between 1.93 and 25.6?μM. Further, one compound was identified as a promising drug lead which showed promising cytotoxicity with IC50 value of 1.93?μM towards MCF-7 breast cancer cell line as compared to the standard drug doxorubicin (IC50 value 0.98?μM). While, all these new compounds showed no cytotoxicity on the normal human embryonic kidney cell line, HEK-293. Graphical abstract: [Figure not available: see fulltext.]

Synthesis and anticancer evaluation of indazole-aryl hydrazide-hydrazone derivatives

A new series of hydrazide-hydrazones linked between indazole and substituted benzaldehydes were designed, synthesized and evaluated for their cytotoxicity against four human cancer cell lines (HeLa, MDA-MB-231, MCF-7 and A549). Among the synthesized compo