677702-36-2

Usage

Uses

Used in Organic Synthesis:
5-Nitro indazole carboxaldehyde is used as a key intermediate in organic synthesis for the creation of various chemical compounds. Its reactivity and functional groups make it a valuable building block in the synthesis of complex organic molecules.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 5-Nitro indazole carboxaldehyde is utilized as a research compound to explore its potential therapeutic applications. Its structure allows for the investigation of its interactions with biological targets, which can lead to the discovery of new drugs.
Used in Bactericidal Applications:
5-Nitro indazole carboxaldehyde is used as a bactericidal agent against certain strains of bacteria. Its ability to kill or inhibit bacterial growth makes it a candidate for use in antimicrobial formulations and treatments.
Used in Antitumor Research:
5-Nitro indazole carboxaldehyde is studied for its potential as an antitumor agent. Research into its effects on tumor cells and its mechanisms of action can contribute to the development of new cancer therapies.
Used in Parasite Growth Inhibition:
5-Nitro indazole carboxaldehyde has been investigated for its ability to inhibit the growth of certain parasitic organisms. This application could lead to the development of new treatments for parasitic infections.
Used in Pharmaceutical Development:
Due to its unique structure and reactivity, 5-Nitro indazole carboxaldehyde is used in the development of new pharmaceuticals. Its potential to interact with biological targets makes it a promising candidate for the creation of novel drugs with specific therapeutic effects.
Used in Agrochemical Development:
5-Nitro indazole carboxaldehyde is also utilized in the development of new agrochemicals. Its potential applications in this industry could include the creation of pesticides or other agricultural chemicals to protect crops and enhance agricultural productivity.

InChI:InChI=1/C8H5N3O3/c12-4-8-6-3-5(11(13)14)1-2-7(6)9-10-8/h1-4H,(H,9,10)

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 5401-94-5 5-nitroindazole 
• 6146-52-7 5-nitroindole 

Downstream Products

• 677702-37-3 5-Nitro-1-(2,4,6-trimethylbenzenesulphonyl)-1H-indazole-3-carbaldehyde 
• 78155-75-6 methyl 5-nitro-1H-indazole-3-carboxylate 

Relevant academic research and scientific papers

Synthesis, antitumor evaluation, and molecular docking studies of indole–indazolyl hydrazide–hydrazone derivatives

Abstract: A series of ten novel hydrazide–hydrazones linked indole and indazole moieties were designed and synthesized. All the synthesized compounds were evaluated for their cytotoxicity against four human cancer cell lines (HeLa, MDA-MB-231, MCF-7, and A549). Three of the synthesized compounds showed promising cytotoxicity specifically on some of the tested cell lines with IC50 values ranging between 1.93 and 25.6?μM. Further, one compound was identified as a promising drug lead which showed promising cytotoxicity with IC50 value of 1.93?μM towards MCF-7 breast cancer cell line as compared to the standard drug doxorubicin (IC50 value 0.98?μM). While, all these new compounds showed no cytotoxicity on the normal human embryonic kidney cell line, HEK-293. Graphical abstract: [Figure not available: see fulltext.]

An optimized procedure for direct access to 1: H -indazole-3-carboxaldehyde derivatives by nitrosation of indoles

Indazole derivatives are currently drawing more and more attention in medicinal chemistry as kinase inhibitors. 1H-indazole-3-carboxaldehydes are key intermediates to access to a variety of polyfunctionalized 3-substituted indazoles. We report here a general access to this motif, based on the nitrosation of indoles in a slightly acidic environment. These very mild conditions allow the conversion of both electron-rich and electron-deficient indoles into 1H-indazole-3-carboxaldehydes.

Synthesis and anticancer evaluation of indazole-aryl hydrazide-hydrazone derivatives

A new series of hydrazide-hydrazones linked between indazole and substituted benzaldehydes were designed, synthesized and evaluated for their cytotoxicity against four human cancer cell lines (HeLa, MDA-MB-231, MCF-7 and A549). Among the synthesized compo

Indazolecarboxamide derivatives, preparation and use thereof as CDK1, CDK2 and CDK4 inhibitors

Compound corresponding to general formula (I): [image] in which, R1 represents a hydrogen or halogen atom, an NH2, NHR2, NHCOR2, NO2, CN, CH2NH2 and CH2NHR2; or alternatively R1 represents an optionally substituted phenyl or an optionally substituted heteroaromatic group; Ar represents an optionally substituted phenyl group or an optionally substituted heteroaromatic group; n represents 0, 1, 2 or 3; in the form of a base, of an addition salt with an acid, of a hydrate or of a solvate. Application in therapy.