677707-79-8

Basic information

• Product Name: 2-[(2R,6S)-6-((R)-2-Benzyloxy-pent-4-enyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid 2-trimethylsilanyl-ethyl ester
• Synonyms: 2-[(2R,6S)-6-((R)-2-Benzyloxy-pent-4-enyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid 2-trimethylsilanyl-ethyl ester
• CAS NO: 677707-79-8
• Molecular Weight: 446.703
• Mol File: 677707-79-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-[(2R,6S)-6-((R)-2-Benzyloxy-pent-4-enyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid 2-trimethylsilanyl-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(2R,6S)-6-((R)-2-Benzyloxy-pent-4-enyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid 2-trimethylsilanyl-ethyl ester(677707-79-8)
• EPA Substance Registry System: 2-[(2R,6S)-6-((R)-2-Benzyloxy-pent-4-enyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid 2-trimethylsilanyl-ethyl ester(677707-79-8)

Safety Data

• Hazardous Substances Data: 677707-79-8(Hazardous Substances Data)

Upstream product

• 677707-77-6 3-[4-(tert-butyl-dimethyl-silanyloxy)-1-(1-methoxycarbonyl-1-methyl-ethyl)-butoxy]-acrylic acid methyl ester 
• 677707-76-5 6-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-2,2-dimethyl-hexanoic acid methyl ester 
• 863659-93-2 (R)-6-Iodo-3-((E)-2-methoxycarbonyl-vinyloxy)-2,2-dimethyl-hexanoic acid methyl ester 
• 677707-78-7 2-((2R,6S)-6-Methoxycarbonylmethyl-tetrahydro-pyran-2-yl)-2-methyl-propionic acid methyl ester 
• 863659-97-6 2-[(2R,6S)-6-((R)-2-Hydroxy-pent-4-enyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid methyl ester 
• 863661-93-2 2-((2R,6S)-6-Carboxymethyl-tetrahydro-pyran-2-yl)-2-methyl-propionic acid methyl ester 
• 863662-20-8 methyl 2-[(2R,6S)-tetrahydro-6-(2-hydroxyethyl)-2H-pyran-2-yl]-2-methylpropanoate 
• 863659-96-5 2-Methyl-2-[(2R,6S)-6-(2-oxo-ethyl)-tetrahydro-pyran-2-yl]-propionic acid methyl ester 
• 863662-27-5 2-[(2R,6S)-6-((R)-2-Benzyloxy-pent-4-enyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid methyl ester 
• 2916-68-9 2-(Trimethylsilyl)ethanol 

Downstream Products

• 863660-52-0 2-Hydroxy-6-[3-((2S,6S)-6-vinyl-tetrahydro-pyran-2-yl)-propyl]-benzoic acid (1R,2S)-1-((S)-2-benzyloxy-3-{(2S,6R)-6-[1-methyl-1-(2-trimethylsilanyl-ethoxycarbonyl)-ethyl]-tetrahydro-pyran-2-yl}-propyl)-2-methyl-but-3-enyl ester 
• 677707-80-1 2-[(2R,6S)-6-((2R,4R,5S)-2-Benzyloxy-4-hydroxy-5-methyl-hept-6-enyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid 2-trimethylsilanyl-ethyl ester 
• 863663-03-0 2-{(2R,6S)-6-[(2S,4R,5S)-2-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-5-methyl-hept-6-enyl]-tetrahydro-pyran-2-yl}-2-methyl-propionic acid 2-trimethylsilanyl-ethyl ester 
• 863663-04-1 2-{(2R,6S)-6-[(2S,4R,5R)-2-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-5-methyl-6-oxo-hexyl]-tetrahydro-pyran-2-yl}-2-methyl-propionic acid 2-trimethylsilanyl-ethyl ester 
• 863660-54-2 2-{(2R,6S)-6-[(2S,4R,5S)-2-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-6-hydroxy-5-methyl-hexyl]-tetrahydro-pyran-2-yl}-2-methyl-propionic acid 2-trimethylsilanyl-ethyl ester 
• 863663-07-4 2-{(2R,6S)-6-[(2S,4R,5R)-6-(Benzothiazol-2-ylsulfanyl)-2-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-5-methyl-hexyl]-tetrahydro-pyran-2-yl}-2-methyl-propionic acid 2-trimethylsilanyl-ethyl ester 
• 863660-55-3 2-{(2R,6S)-6-[(2S,4R,5R)-6-(Benzothiazole-2-sulfonyl)-2-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-5-methyl-hexyl]-tetrahydro-pyran-2-yl}-2-methyl-propionic acid 2-trimethylsilanyl-ethyl ester 
• 677707-87-8 2-[6-(2-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-7-{6-[3-(2,2-dimethyl-4-oxo-4H-benzo[1,3]dioxin-5-yl)-propyl]-tetrahydro-pyran-2-yl}-5-methyl-heptyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid 2-trimethylsilanyl-ethyl ester 
• 863663-09-6 C₇₉H₁₂₈O₁₃Si₃ 
• 863660-76-8 C₇₃H₁₁₄O₁₃Si₂ 
• 863660-58-6 2-[6-(2-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-7-{6-[3-(2,2-dimethyl-4-oxo-4H-benzo[1,3]dioxin-5-yl)-propyl]-tetrahydro-pyran-2-yl}-5-methyl-hept-6-enyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid 2-trimethylsilanyl-ethyl ester 
• 863659-98-7 2-[(2R,6S)-6-((S)-2-Benzyloxy-4-oxo-butyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid 2-trimethylsilanyl-ethyl ester 

Relevant articles and documents

Stereoselective synthesis of (+)-SCH 351448: A unique ligand system for sodium, calcium, and other cations

(+)-SCH 351448 (Na+ salt A) was synthesized employing ring-closing olefin metathesis reaction of an open diene diester intermediate for construction of the 28-membered macrodiolide structure. The open diene diester was prepared from the monomeric hydroxy carboxylic acid and two different olefin fragments. The monomeric hydroxy acid was synthesized via Julia-Julia coupling reaction of intermediates derived from the same olefinic fragments. Oxane units in these fragments were prepared by radical cyclization reactions of β-alkoxyacrylates. Analogous SCH 351448 salts incorporating other mono- and divalent cations may be prepared. Under acidic conditions, SCH 351448 (Na+ salt A) was the most stable complex, but SCH 351448 (Ca2+ salt) and (Na+ salt B) appear to be physiologically important species.