677708-75-7

Upstream product

• 865786-99-8 1-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)-2-(2-nitro-phenyl)-ethanone 
• 103-82-2 phenylacetic acid 
• 3740-52-1 2-(2-nitrophenyl)acetic acid 
• 69628-96-2 p-toluenesulfonic acid o-nitrophenethyl ester 
• 87691-88-1 3-(1-piperazinyl)-1,2-benzisothiazole hydrochloride 

Downstream Products

• 677708-76-8 2-[2-(4-1,2-benzisothiazol-3-yl-piperazin-1-yl)-ethyl]-phenylamine 
• 884324-89-4 N-{2-[2-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-phenyl}-acrylamide 
• 690972-26-0 3-methyl-but-2-enoic acid {2-[2-(4-1,2-benzisothiazol-3-yl-piperazin-1-yl)-ethyl]-phenyl}-amide 
• 677708-72-4 {2-[2-(4-1,2-benzisothiazol-3-yl-piperazin-1-yl)-ethyl]-phenyl}-3-chloro-propionamide 
• 677708-73-5 {2-[2-(4-1,2-benzisothiazol-3-yl-piperazin-1-yl)-ethyl]-phenyl}-3-chloro-2,2-dimethyl-propionamide 
• 677708-74-6 N-{2-[2-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-phenyl}-3-phenyl-acrylamide 
• 677708-84-8 8-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-4-Phenyl-1,2,3,4-tetrahydro-quinoline 
• 677708-39-3 8-[2-(4-1,2-benzisothiazol-3-yl-piperazin-1-yl)-ethyl]-4-phenyl-3,4-dihydro-1H-quinolin-2-one 

Relevant academic research and scientific papers

8-Substituted 3,4-dihydroquinolinones as a novel scaffold for atypical antipsychotic activity

Several new, potent dopamine subtype 2 (DA D2) active compounds with serotonin subtype 2A (5-HT2A) pharmacology are presented. 8-Substituted 3,4-dihydroquinolinones, tetrahydroquinolines, and N-acyl tetrahydroquinolines were evaluated in primary assays. Subtle changes on this novel scaffold translated to large changes in potency and selectivity in vitro. These compounds show promise as novel atypical antipsychotics for the treatment of schizophrenia.

Heterocyclic substituted piperazines for the treatment of schizophrenia

This invention relates to compounds of the formula 1 wherein Ar, A, R2, R3, Y and ring Q are defined as in the specification, pharmaceutical compositions containing them and their use in the treatment of central nervous system disord

PHENYLALKYL AND PYRIDYLALKYL PIPERAZINE DERIVATIVES

This invention relates to compounds of the formula (1) wherein R1, R3, R4, X1, and X2 are defined as in the specification, pharmaceutical compositions containing them and their use in the treatment of central nervous system and other disorders.