677728-92-6

Basic information

• Product Name: 2-Fluoropyridine-5-carboxaldehyde
• Synonyms: 2-FLUORO-5-FORMYLPYRIDINE;2-FLUOROPYRIDINE-5-CARBALDEHYDE;2-Fluoropyridine-5-carboxaldehyde;3-Pyridinecarboxaldehyde,6-fluoro-(9CI);6-Fluoronicotinaldehyde;2-Fluoro-5-pyridinecarboxaldehyde;6-Fluoropyridine-3-Carboxaldehyde;6-fluoropyridine-3-carbaldehyde
• CAS NO: 677728-92-6
• Molecular Formula: C₆H₄FNO
• Molecular Weight: 125.1
• Product Categories: PYRIDINE;pharmacetical;Building Blocks;Fluorinated;Fluorine series;organic building block
• Mol File: 677728-92-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 228.963 °C at 760 mmHg
• Flash Point: 92.274 °C
• Appearance: /
• Density: 1.27 g/cm³
• Vapor Pressure: 0.071mmHg at 25°C
• Refractive Index: 1.544
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -2.23±0.10(Predicted)
• CAS DataBase Reference: 2-Fluoropyridine-5-carboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoropyridine-5-carboxaldehyde(677728-92-6)
• EPA Substance Registry System: 2-Fluoropyridine-5-carboxaldehyde(677728-92-6)

Safety Data

• Hazard Codes: Xi
• RIDADR: 1993
• HazardClass: 3
• PackingGroup: Ⅲ
• Hazardous Substances Data: 677728-92-6(Hazardous Substances Data)

Usage

Uses

6-Fluoro-3-pyridinecarboxaldehyde is used in the synthetic preparation of biheteroaryl arylamines as selective inhibitors of phosphoinositol 3-kinases (PI3K), which are selective for PI3K over mTOR and have potential use as antitumor agents.

InChI:InChI=1/C6H4FNO/c7-6-2-1-5(4-9)3-8-6/h1-4H

Upstream product

• 766-11-0 5-bromo-2-fluoropyridine 
• 107-31-3 Methyl formate 
• 39891-05-9 (6-fluoropyridin-3-yl)methanol 
• 403-45-2 6-fluoronicotinic acid 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 1375702-84-3 2-[6-(4-benzylpiperazin-1-yl)pyridin-3-yl]-5-methoxy-3H-imidazo[4,5-b]pyridine 
• 1133879-66-9 2-fluoro-5-vinylpyridine 
• 1188327-59-4 (S)-N-{3-[3-fluoro-4-(5-formyl-pyridin-2-yloxy)phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide 

Relevant articles and documents

Lewis basicity modulation of N-heterocycles: A key for successful cross-metathesis

Cross-metathesis involving N-heteroaromatic olefinic derivatives is disclosed. The introduction of an appropriate substituent on the heteroaromatic ring decreases the Lewis basicity of the nitrogen atom, thus preventing the deactivation of the ruthenium-centered catalyst. The reaction is quite general in terms of both N-heterocycles and olefinic partners.

TRPA1 ANTAGONISTS

Compounds of formula (I), wherein R1, R2, R3, and Y are defined in the description are TRPA1 antagonists. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.