677737-60-9

Upstream product

• 146903-56-2 (E)-2-<(3,4,5-trimethoxyphenyl)methylene>hydrazinecarboximidamide 
• 70-11-1 α-bromoacetophenone 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 146903-56-2 (E)-2-(3,4,5-trimethoxybenzylidene)hydrazine-1-carboximidamide 

Relevant academic research and scientific papers

Rational Design and Synthesis of 1-(Arylideneamino)-4-aryl-1H-imidazole-2-amine Derivatives as Antiplatelet Agents

Based on previous studies indicating the pharmacophoric role of a hydrazone group and azole rings for antiplatelet aggregation activity, a few series of compounds with both hydrazone and an azole (imidazole) ring in their structures were synthesized, and their platelet aggregation inhibitory effects were evaluated. Two of these 1-(arylideneamino)-4-aryl-1H-imidazole-2-amine derivatives, compounds 4 a [(E)-1-(benzylideneamino)-4-phenyl-1H-imidazol-2-amine] and 4 p [(E)-4-phenyl-1-((thiophen-2-ylmethylene)amino)-1H-imidazol-2-amine], exhibited IC50 values similar to that of acetylsalicylic acid against collagen as a platelet aggregation inducer. Structural comparison of the synthesized compounds revealed that those with a para-substituted phenyl ring on the imidazole were among the most active compounds against platelet aggregation induced by arachidonic acid (AA), and the presence of a thiophene ring in these compounds maximized their antiplatelet activity.

2-Amino-4-aryl-1-arylideneaminoimidazoles and Acylation Products: A Multinuclear (1H, 13C, 15N) NMR Study

The structure of 2-amino-4-aryl-1-arylideneaminoimidazoles in DMSO-d 6 solution was investigated by means of NMR spectroscopic methods (1H, 13C, 15N). From these data the (E)-configuration at the excocyclic C=N