677746-35-9 Usage
Uses
Used in Chemical and Biochemical Research:
Boronic acid, (2-methoxy-5-nitrophenyl)(9CI) is used as a research compound for exploring its potential interactions with sugars, amino acids, and other biological molecules. Its ability to form stable covalent complexes is of interest in the development of new chemical and biochemical applications.
Used in Pharmaceutical Development:
While the specific applications, effects, and safety details of Boronic acid, (2-methoxy-5-nitrophenyl)-, are not extensively reported, its potential use in pharmaceutical development is acknowledged. Boronic acid, (2-methoxy-5-nitrophenyl)(9CI) may be utilized as a starting material or intermediate in the synthesis of more complex molecules with therapeutic potential.
Used in Material Science:
Given the general properties of boronic acids, Boronic acid, (2-methoxy-5-nitrophenyl)(9CI) could be used in material science for the development of new materials with unique properties, such as those that can interact with biological systems or exhibit specific chemical reactivity.
Check Digit Verification of cas no
The CAS Registry Mumber 677746-35-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,7,7,7,4 and 6 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 677746-35:
(8*6)+(7*7)+(6*7)+(5*7)+(4*4)+(3*6)+(2*3)+(1*5)=219
219 % 10 = 9
So 677746-35-9 is a valid CAS Registry Number.
677746-35-9Relevant academic research and scientific papers
The Design of Boronic Acid Spectroscopic Reporter Compounds by Taking Advantage of the pKa-Lowering Effect of Diol Binding: Nitrophenol-Based Color Reporters for Diols
Ni, Weijuan,Fang, Hao,Springsteen, Greg,Wang, Binghe
, p. 1999 - 2007 (2007/10/03)
The complex that forms between a boronic acid and a diol is often much more acidic than the starting boronic acid. In conditions where the solution pH is between the two pKa values, the boron atom will convert from a neutral trigonal form to an anionic tetrahedral form upon complexation. Such a change is likely to dramatically alter the electron density of neighboring groups. Utilizing this effect, we have designed and synthesized two nitrophenol-based boronic acid reporter compounds that change ionization states and therefore spectroscopic properties upon diol binding. Both compounds show significant UV changes upon addition of saccharides. For example, a blue shift of the absorption max from 373 to 332 nm was observed with the addition of D-fructose to 2-hydroxy-5-nitrophenylboronic acid at neutral pH. Such a reporter compound can be used as a recognition and signaling unit for the construction of polyboronic acid sensors for the selective and specific recognitions of saccharides of biological significance.
