677751-80-3

Upstream product

• 672337-39-2 (3aR,6aS)-6a-((R)-1-Methoxymethoxy-ethyl)-2,2-dimethyl-3a,6a-dihydro-cyclopenta[1,3]dioxol-4-one 
• 111136-75-5 (-)-(1R,2R,6R,7S)-tricyclo[5.2.1.0^2,6]deca-4,8-dien-3-one 
• 672337-29-0 (3aS,4R,7S,7aR)-3-Acetyl-3a,4,7,7a-tetrahydro-4,7-methano-inden-1-one 
• 672337-27-8 (3R,3aS,4R,7S,7aR)-3-Vinyl-2,3,3a,4,7,7a-hexahydro-4,7-methano-inden-1-one 
• 672337-30-3 (1R,3aS,4R,7S,7aR)-3-((R)-1-Hydroxy-ethyl)-3a,4,7,7a-tetrahydro-1H-4,7-methano-inden-1-ol 
• 672337-16-5 C₁₂H₁₅BrO₂ 
• 672337-34-7 C₁₄H₁₉BrO₃ 
• 672337-37-0 C₁₇H₂₆O₅ 
• 672337-38-1 C₁₇H₂₄O₅ 
• 672337-35-8 C₁₄H₂₁BrO₅ 
• 672337-36-9 C₁₇H₂₅BrO₅ 
• 677752-14-6 (4S,5R,6S)-6-(tert-Butyl-dimethyl-silanyloxy)-2,2,4-trimethyl-1,3-dioxa-spiro[4.4]non-8-en-7-one 
• 677752-02-2 (E)-4-((4R,5S)-2,2,5-Trimethyl-[1,3]dioxolan-4-yl)-but-3-en-2-one 
• 677752-03-3 4-((4R,5S)-2,2,5-Trimethyl-[1,3]dioxolan-4-yl)-butan-2-one 

Relevant academic research and scientific papers

Stereoselective approach to pentenocins using RCM: synthesis of 6-epi-pentenocin B

The stereoselective synthesis of 6-epi-pentenocin B 3 is described using a stereoselective Grignard reaction and ring-closing metathesis (RCM) as the key steps.

Total Synthesis and Absolute Stereochemistry of Pentenocin B, a Novel Interleukin-1β Converting Enzyme Inhibitor

Four possible diastereomers of pentenocin B were synthesized in a stereocontrolled manner, and the first total synthesis of a natural enantiomer of (+)-pentenocin B unequivocally established the absolute stereochemistry to be 4S,5R,6R.

Synthesis and structure of diastereomers of pentenocin B produced by Trichoderma hamatum FO-6903

All diastereomers of pentenocin B, an inhibitor of interleukin-1β converting enzyme produced by Trichoderma hamatum FO-6903, were synthesized in chiral forms starting from L-threonine. Absolute configurations of natural pentenocin B were clarified to be 4S, 5R, and 6R.